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FLASH GENE
Symbol PLAC8 contributors: np/ - updated : 05-02-2005
HGNC name placenta-specific 8
HGNC id 19254
Location 4q21.22      Physical location : 84.011.212 - 84.035.911
Synonym name
  • onzin
  • protein C15
  • Synonym symbol(s) BM-004, C15, onzin
    DNA
    TYPE functioning gene
    STRUCTURE 24.71 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure sites for widely-expressed transcription factors which, by analogy to other instances, may be sufficient to explain placental enrichment
    MAPPING cloned Y linked N status provisional
    Physical map
    MRPS25P1 4q21.23 mitochondrial ribosomal protein S25 pseudogene MGC35043 4q21.3 hypothetical protein MGC35043 BMP3 4p14-q21 bone morphogenetic protein 3 (osteogenic) PRKG2 4q13.1-q21.1 protein kinase, cGMP-dependent, type II GPIG4 COX5BL1 4cen-q31 cytochrome c oxidase subunit Vb-like 1 LOC345258 4q21.3 similar to bridging integrator 2; bridging integrator-2; breast cancer associated protein BRAP1 HNRPD 4q21.1-q21.2 heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) LOC391672 4 similar to Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (B cell signal transduction molecule alpha 4) (Alpha 4 protein) HNRPDL 4q13-q21 heterogeneous nuclear ribonucleoprotein D-like MASA 4q21.3 E-1 enzyme LOC391673 4 similar to protein-tyrosine phosphatase SCD4 4q21.3 stearoyl-CoA desaturase 4 KIAA0905 4q21.3 stearoyl-CoA desaturase 4 THAP9 4q21.3 THAP domain containing 9 DKFZp686L1814 4q21.3 hypothetical protein DKFZp686L1814 COPS4 4q21.21-q21.23 COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) PLAC8 4q21.22 placenta-specific 8 LOC391674 4 similar to Aminomethyltransferase, mitochondrial precursor (Glycine cleavage system T protein) (GCVT) CL640 4q21.3 hypothetical protein CL640 HPSE 4q21.3 heparanase HEL308 4q21.3 DNA helicase HEL308 MRPS18C 4q21.3 mitochondrial ribosomal protein S18C FLJ13614 4q21.21-q21.23 hypothetical protein FLJ13614 MGC11324 4q21.3 hypothetical protein MGC11324 LOC152845 4q21.3 similar to product similar to X.laevis finger protein. NKX6-1 4q21.2-q22 NK6 transcription factor related, locus 1 (Drosophila) CDS1 4q21 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 WDFY3 4q21.23 WD repeat and FYVE domain containing 3 LOC391675 4 LOC391675
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1003 - 115 - -
    5 - 1442 - 115 - -
    5 - 1403 - 115 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmyelocyte Homo sapiens
    cell lineage highly expressed in myeloid cells )
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative signal peptides
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in placenta development and fetus maternal interface
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negative MYC target
  • interaction with and activation of AKT1 and MDM2, and down-regulates TP53
  • PLSCR1 interacts with the same cysteine-rich domain of PLAC8 as do AKT1 and MDM2, whereas the PLAC8-interacting domain of PLSCR1 centers around, but does not require, a previously identified palmitoylation signal
  • cell & other
    REGULATION
    Other regulated by PLSCR1 (physiologic regulator of PLAC8, with a functional interdependence between PLAC8 and PLSCR1)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS