Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLAC1 contributors: mct - updated : 06-05-2014
HGNC name placenta-specific 1
HGNC id 9044
Location Xq26.3      Physical location : 133.699.872 - 133.792.513
Synonym name
  • cancer/testis antigen 92
  • Synonym symbol(s) CT92, OOSP2L
    DNA
    TYPE functioning gene
    STRUCTURE 92.64 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box) (TATA box)
    text structure
  • two promoters, P1 and P2, separated by 105 kb; P1 and P2 are activated by RXRA in conjunction with LXRA or LXRB
  • placental tissues favor P2 transcripts, while P1 is favored in most of the other cells
  • MAPPING cloned Y linked N status provisional
    Map cen - GPC3 - HPRT1 - PLAC1 - qter
    Authors Cocchia (00)
    regionally located 65kb telomeric to HPRT
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1126 - 212 - 2000 10995572
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Mus musculusFetal
    Digestiveintestinelarge intestinecolon   Mus musculusFetal
     liver     Mus musculusFetal
    Nervousbrain     Mus musculusFetal
    Reproductivefemale systemplacenta  specific Homo sapiens
    Urinarykidney     Mus musculusFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, neonatal, pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    signal peptide and a sequence,also found of the zona pellucida 3 protein an interaction domain
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Plac1
    intraspecies homolog to zona pellucida 3 ((Zp3)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text
  • localizes to the microvillus membrane surface of the syncytiotrophoblast in direct proximity to the maternal compartment
  • localized to the apical surface of the epithelial cells lining the developing airways of the lung and proximal renal tubules, consistent with its localization in the differentiated syncytiotrophoblast
  • basic FUNCTION
  • involved in placenta development and fetus maternal interface
  • paternally imprinted, X-linked gene essential for normal placental and embryonic development
  • role for PLAC1 in the maintenance of the maternal-fetal interface
  • essential for normal placental development
  • central role for PLAC1 in establishment and maintenance of the placenta
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF7 and its receptor, FGFR2, exhibited spatial overlap with PLAC1 suggesting these regulatory interactions are physiologically relevant during gestation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    is associated with placentomegaly and intrauterine growth retardation
    constitutional     --low  
    is linked to increased risk for hydrocephalus
    constitutional     --over  
    increased circulating levels of human PLAC1 mRNA in maternal blood are associated with preeclampsia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential role for PLAC1 as a biomarker predictive of specific pregnancy complications, such as preeclampsia
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for both active and passive cancer immunotherapeutic strategies
    ANIMAL & CELL MODELS
  • Plac1-null mice exhibit reduced postnatal viability
  • PLAC1-null mice exhibit decreased viability in the peripartum period suggesting a role in pregnancy maintenance late in gestation