Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLAA contributors: mct/npt - updated : 06-06-2017
HGNC name phospholipase A2-activating protein
HGNC id 9043
Corresponding disease
PLAAND PLAA-associated neurodevelopmental disorder
Location 9p21.2      Physical location : 26.903.368 - 26.947.468
Synonym name DOA1 homolog
Synonym symbol(s) PLAP, PLA2P, FLJ11281, FLJ12699, DOA1
DNA
TYPE functioning gene
STRUCTURE 44.10 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - IFN1@ - CDKN2A - CDKN2B - D9S1870 - D9S171 - D9S1679 - D9S265 - D9S259 - PLAA - cen
Authors Beatty (99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4954 87.1 795 - 1999 10644453
13 - 4808 - 772 - 1999 10644453
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • WD40 repeat motifs at the N terminus
  • three different protein kinase consensus domains
  • a core domain from the PLAA family ubiquitin-binding region of human PLAA (AAs 386-465, namely PFUC) that can bind Ub
  • HOMOLOGY
    interspecies ortholog to yeast Doa1/Ufd3
    Homologene
    FAMILY
  • beta transducin protein superfamily
  • WD repeat PLAP family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • signaling molecule that regulates the production of prostaglandins (PGE(2)) and tumor necrosis factor (TNF1)
  • required for 1alpha,25(OH)2D3 signaling in growth plate chondrocytes
  • specific activator of PLA2 in growth plate chondrocytes, and may mediates the membrane effect of 1alpha,25(OH)2D3, thereby modulating physiological response
  • is required for ubiquitin-dependent trafficking of receptors from early to late endosomes/multivesicular bodies (MVBs)
  • conserved role for mammalian PLAA in Ub-mediated trafficking of membrane proteins though the endolysosomal pathway, and it is essential for mammalian embryonic development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is required for 1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via PDIA3
  • PLAA is located in caveolae, where it interacts with PDIA3 and CAV1 to initiate rapid signaling via CAMK2A, CAMK2B
  • VCP/p97 cooperates with YOD1, UBXN6 and PLAA to drive clearance of ruptured lysosomes by autophagy
  • cell & other
    REGULATION
    induced by TNF-alpha can perpetuate inflammation by enhancing activation of PLA(2) and NF-kappaB
    ASSOCIATED DISORDERS
    corresponding disease(s) PLAAND
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plaa-null mice were perinatal lethal with reduced brain levels of prostaglandin E2