Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLA2R1 contributors: mct/npt - updated : 12-06-2009
HGNC name phospholipase A2 receptor 1, 180kDa
HGNC id 9042
Location 2q24.2      Physical location : 160.798.011 - 160.919.121
Synonym name
  • M-type receptor
  • 180 kDa secretory phospholipase A2 receptor
  • Synonym symbol(s) PLA2R, PLA2-R, PLA2IR, PLA2G1R, CLEC13C
    DNA
    TYPE functioning gene
    STRUCTURE 121.11 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    PSCDBP 2q11.2 pleckstrin homology, Sec7 and coiled-coil domains, binding protein ACVR1C 2q24-q31 activin A receptor, type IC ACVR1 2q23-q24 activin A receptor, type I UPP2 2q24.2 uridine phosphorylase 2 LOC130940 2q24.2 hypothetical protein BC015395 PKP4 2q23-q31 Plakophilin 4 LOC391456 2 similar to KIAA0181 LOC92196 2q24.2 similar to death-associated protein OR7E89P 2q31.3 olfactory receptor, family 7, subfamily E, member 89 pseudogene LOC391457 2 similar to putative taste receptor HTR2 OR7E90P 2q31.3 olfactory receptor, family 7, subfamily E, member 90 pseudogene MGC23908 2 similar to RNA polymerase B transcription factor 3 KIAA1728 2q24.2 KIAA1728 protein FLJ36175 2q24.2 hypothetical protein FLJ36175 BAZ2B 2q23-q24 bromodomain adjacent to zinc finger domain, 2B AXOT 2q24.2 axotrophin DCL-1 2q24.2 type I transmembrane C-type lectin receptor DCL-1 LY75 2p24 lymphocyte antigen 75 PLA2R1 2q23-q24.1 phospholipase A2 receptor 1, 180kDa ITGB6 2q24-q31 integrin, beta 6 RBMS1 2q24.2 RNA binding motif, single stranded interacting protein 1 TANK 2q24-q31 TRAF family member-associated NFKB activator PSMD14 2q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 TBR1 2q24 T-box, brain, 1 LOC285116 2q24.3 ELYS transcription factor-like protein TMBS62 pseudogene LOC391458 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SLC4A10 2q23-q24 solute carrier family 4, sodium bicarbonate transporter-like, member 10 DPP4 2q24.3 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) GCG 2q36-q37 glucagon FAP 2q23 fibroblast activation protein, alpha MDA5 2p24.3-q24.3 melanoma differentiation associated protein-5
    RNA
    TRANSCRIPTS type messenger
    text with soluble and membrane bound isoforms (Ancian 1995)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 4876 166 1463 - Ancian, Silliman (2002)
  • a 25 aa signal peptide (2.5 kda)
  • a 1438 mature peptide (166.1 kda)
  • 30 exons
  • transmembrane protein (a C-terminal transmembrane region)
  • 15 potential N-glycosylation sites
  • an N-terminal cysteine-rich domain
  • a fibronectin-like type II domain
  • 8 carbohydrate recognition domains
  • a short C-terminal cytoplasmic tail containing a consensus sequence (asn-pro-X-tyr)
  • 27 polyA site 5160 150 1324 - Ancian, Silliman (2002)
  • a 25 signal peptide (2.5 kda)
  • a 1299 aa mature peptide (150.3 kda)
  • 27 exons
  • using an alternate splice site in the 3' coding region compared to variant 1
  • encoding a secreted isoform (lacking a C-terminal transmembrane region found in isoform 1)
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon highly
    Endocrineparathyroid   predominantly
    Reproductivefemale systembreastmammary gland moderately
    Respiratorynasopharynx   moderately
     respiratory tractlarynx  highly
     respiratory tracttrachea  highly
    Urinarykidney   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • an N terminal cysteine domain
  • a fibronectin-like type II domain
  • a shorter secreted form with the same binding properties
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Mrc2 (73.2pc)
    homolog to murine Pla2g1br (73.8pc)
    Homologene
    FAMILY
    CATEGORY enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text integral to plasma membrane
    basic FUNCTION
  • acting as a phospholipase receptor
  • presence on neutrophils and having role in elastase release and adhesion (Silliman 2002)
  • regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s) (Hanasaki 2004)
  • potential new tumour suppressor gene crucial in the induction of cellular senescence through the activation of the TP53 pathway (Augert 2009)
  • genetically modifying the expression has an important impact on the senescence of primary cells (Augert 2009)
  • could regulate senescence by controlling the production of cytokines, as is able to regulate cytokines (cytokines are involved in senescence outcome) and is a new crucial regulator of senescence in human primary cells (Augert 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • sugar
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to premature coronary artery disease in the absence of hypercholesterolemia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS