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FLASH GENE
Symbol PLA2G5 contributors: mct - updated : 16-12-2011
HGNC name phospholipase A2, group V
HGNC id 9038
Corresponding disease
BFLR benign fleck retina
Location 1p36.13      Physical location : 20.396.700 - 20.418.393
Synonym name
  • phosphatidylcholine 2-acylhydrolase
  • calcium-dependent phospholipase A2
  • Synonym symbol(s) GV-PLA2, PLA2-10, hVPLA(2)
    EC.number 3.1.1.4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    STRUCTURE 21.70 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure opposite orientation with PLA2G2A
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1911 14 138 - 2000 11080676
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Endocrineadrenal gland    
    Reproductivefemale systemplacenta   
     male systemtestis   
    Respiratorylung   lowly Homo sapiens
    Visualeyeretina  highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Respiratoryalveolar cell type 2
    Visualganglion cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve cysteine residues forming six disulfide bonds
  • 20 AA leader peptides
  • HOMOLOGY
    interspecies homolog to murine Pla2g5
    Homologene
    FAMILY phospholipase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    basic FUNCTION
  • involved in the production of lung surfactant and the remodeling or regulation of cardiac muscle
  • inducing leukotriene B4 synthesis in neutrophils
  • plays an essential role in Mycobacterium tuberculosis-mediated ROS generation and inflammatory mediator release by microglial cells
  • in addition to promoting atherosclerotic lipid accumulation in macrophages, its hydrolysis of LDL leads to activation of NFkappaB, a key regulator of inflammation
  • plays an important role in the pathogenesis of myocardial ischaemia-reperfusion injury partly in concert with the activation of PLA2G4A
  • potentially playing a role in the phagocytosis of photoreceptor outer-segment discs by the retinal pigment epithelium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BFLR
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS