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FLASH GENE
Symbol PLA2G4A contributors: mct - updated : 29-03-2016
HGNC name phospholipase A2, group IVA (cytosolic, calcium-dependent)
HGNC id 9035
Corresponding disease
PLA2G4AD PLA2G4A deficiency
Location 1q31.1      Physical location : 186.798.031 - 186.958.105
Synonym name
  • phospholipase A2, group IVA
  • lysophospholipase
  • calcium-dependent phospholipid-binding protein
  • phosphatidylcholine 2-acylhydrolase
  • cytosolic phospholipase A2
  • Synonym symbol(s) PLA2C, PLA2G4, CPLA2, cPLA2-alpha, MGC126350
    EC.number 3.1.1.4, 3.1.1.5
    DNA
    TYPE functioning gene
    STRUCTURE 160.08 kb     18 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RGS8 1q25-q31 regulator of G-protein signalling 8 NPL 1q25 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) DHX9 1q25 DEAH (Asp-Glu-Ala-His) box polypeptide 9 C1orf14 1q25-q31 chromosome 1 open reading frame 14 LOC391143 1 similar to natural cytotoxicity triggering receptor 1; lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46); lymphocyte antigen 94 (mouse) homolog (activating NK-receptor ; NK-p46); lymphocyte antigen 94 homolog, a LOC343326 1q25.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) LAMC1 1q31 laminin, gamma 1 (formerly LAMB2) LAMC2 1q25-q31 laminin, gamma 2 NMNAT2 1q25-q31 nicotinamide nucleotide adenylyltransferase 2 C1orf16 1q25-q31 chromosome 1 open reading frame 16 NCF2 1q25 neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) ARPC5 1q25.2 actin related protein 2/3 complex, subunit 5, 16kDa RGL 1q25.2 actin related protein 2/3 complex, subunit 5, 16kDa C1orf17 1q25-q31 chromosome 1 open reading frame 17 C1orf19 1q25-q31 chromosome 1 open reading frame 19 LOC391144 1 similar to Rho-GTPase-activating protein 8 C1orf21 1q25-q31 chromosome 1 open reading frame 21 C1orf22 1q24-q25 chromosome 1 open reading frame 22 C1orf24 1q25-q31 chromosome 1 open reading frame 24 RNF2 1q25.1 ring finger protein 2 C1orf25 1q25.2 chromosome 1 open reading frame 25 C1orf26 1q25 chromosome 1 open reading frame 26 IVNS1ABP 1q25.1-q31.1 influenza virus NS1A binding protein FIBL-6 1q25.3 hemicentin PRG4 1q25-q31 proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome) TPR 1q25 translocated promoter region (to activated MET oncogene) C1orf27 1q25-q31 translocated promoter region (to activated MET oncogene) PDC 1q32-q41 phosducin LOC391145 1 similar to KIAA1871 protein PTGS2 1q25.2-q25.3 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) PLA2G4A 1q25 phospholipase A2, group IVA (cytosolic, calcium-dependent) LOC343332 1q25.3 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) DBCCR1L 1q25.3 DBCCR1-like
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2940 85 749 - 1991 1869522
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connective    
    Epithelialbarrier/liningendothelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    Blood/Hematopoieticneutrophil
    Blood/Hematopoieticplatelet
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a N terminal calcium dependent lipid-binding/C2 domain
  • a catalytic unit differing from that of other lipases
  • HOMOLOGY
    interspecies homolog to murine pla2g4
    Homologene
    FAMILY
  • cytosolic phospholipase A2 group IV family
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text translocates from cytosol and nucleus to perinuclear membrane vesicles in a calcium-dependent fashion
    basic FUNCTION
  • phospholipase A2, group IV, Ca2+ dependent
  • releasing arachidonic acid from membrane phospholipids
  • initiating the biosynthesis of prostaglandins, leukotrienes and platelet-activating factor and the inflammatory response
  • hydrolyzes arachidonic acid from cellular membrane phospholipids, thereby providing enzymatic substrates for the synthesis of eicosanoids, such as prostaglandins and leukotrienes
  • catalyzes the first step in the arachidonic acid cascade leading to the synthesis of important lipid mediators, the prostaglandins and leukotrienes
  • PLA2G4A and EHD1 are involved in the vesiculation of CD59-containing endosomes
  • PLA2G4A/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum
  • modulates arachidonic acid production, thus tightly regulating the downstream effects of pro- and anti-inflammatory eicosanoids
  • important isoform of PLA2 that mediates the release of arachidonic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HTATIP
  • interacting with KLF11 (silences PLA2G4A and down-regulates PGE2)
  • induces potentially membrane curvature and allows EHD1, possibly in the context of a complex, to sever the curved membranes into vesicles
  • its activity plays a crucial role in the signaling cascade leading to apoptotic neuronal death by aggregated APP probably via activation of N-SMase, ceramide production and caspases-3 and -8
  • osteoblastic cytosolic PLA2G4A is crucially involved in EDN1-induced prostaglandin formation
  • acts as a bridge in the formation of a multiprotein complex at the G2-to-M transition to promote binding of SIRT2 to CCNA2-CDK2
  • cell & other
    REGULATION
    activated by the interaction between MAPK3/MAPK1 couple and KSR1
    increased intracellular Ca2+ levels and phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s) PLA2G4AD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal adenocarcinoma
    constitutional     --over  
    in Alzheimer disease (AD) brain associated with amyloid deposits
    constitutional       loss of function
    attenuates not only lipid deposition in the liver but also hepatic fibrosis formation
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    attractive therapeutic target for ameliorating secondary tissue damage and promoting recovery of function after spinal cord injury
    ANIMAL & CELL MODELS