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FLASH GENE
Symbol PLA2G2A contributors: - updated : 16-02-2006
HGNC name phospholipase A2, group IIA (platelets, synovial fluid)
HGNC id 9031
Location 1p36.1-p35      Physical location : 20.301.924 - 20.306.932
Synonym name phosphatidylcholine 2-acylhydrolase, modifier of MIN1 mouse,homolog
Synonym symbol(s) PLA2B, PPLA2R, MOM1, PLA2L, PA2M
EC.number 3.1.1.4
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
STRUCTURE 5.00 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
text structure opposite orientation with PLA2G5 promoter repressed in hepatocytes
MAPPING cloned Y linked N status confirmed
Map pter - D1S436 - (PLA2G2A - PLA2G5 - PLA2G2C ) - D1S647 - D1S478 - cen
Authors Tischfield (96)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Reproductivemale systemprostate  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
cell lineage
cell lines
fluid/secretion synovial fluid
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
fourteen cysteine residues forming seven disulfide bonds
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Pla2g2a
homolog to chicken pla2g2a
Homologene
FAMILY phospholipase A2 family
CATEGORY enzyme , immunity/defense , tumor suppressor
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • potent mediator of the inflammatory process
  • regulation of the phospholipide metabolism in bio membranes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by enhanced by inflammatory cytokines as well as lipolysaccharides in various cell types
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS