Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | PLA2G2A | contributors: - updated : 16-02-2006 |
HGNC name | phospholipase A2, group IIA (platelets, synovial fluid) |
HGNC id | 9031 |
|
Location | 1p36.1-p35 Physical location : 20.301.924 - 20.306.932 |
Synonym name | phosphatidylcholine 2-acylhydrolase, modifier of MIN1 mouse,homolog |
Synonym symbol(s) | PLA2B, PPLA2R, MOM1, PLA2L, PA2M |
EC.number | 3.1.1.4 |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | opposite orientation |
STRUCTURE | 5.00 kb 6 Exon(s) |
Genomic sequence alignment details |
---|
10 Kb 5' upstream gene genomic sequence study |
regulatory sequence | Promoter (CAAT box) |
text structure | opposite orientation with PLA2G5 promoter repressed in hepatocytes |
MAPPING | cloned | Y | linked | N | status | confirmed |
Map | pter - D1S436 - (PLA2G2A - PLA2G5 - PLA2G2C ) - D1S647 - D1S478 - cen |
Authors | Tischfield (96) |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||
organ(s) |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| synovial fluid | |
at STAGE |
physiological period | pregnancy |
Text | placenta |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| fourteen cysteine residues forming seven disulfide bonds |
conjugated | GlycoP |
HOMOLOGY |
interspecies | homolog to murine Pla2g2a |
homolog to chicken pla2g2a |
Homologene |
FAMILY | phospholipase A2 family |
CATEGORY | enzyme , immunity/defense , tumor suppressor |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane |
basic FUNCTION | |
|
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | inflammation |
PATHWAY |
metabolism | lipid/lipoprotein |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other |
REGULATION |
activated by | enhanced by inflammatory cytokines as well as lipolysaccharides in various cell types |
ASSOCIATED DISORDERS |
corresponding disease(s) |
related resource | MITOP database |
Susceptibility |
Variant & Polymorphism
| |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |