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FLASH GENE
Symbol PLA2G1B contributors: - updated : 11-04-2006
HGNC name phospholipase A2, group IB (pancreas)
HGNC id 9030
Location 12q23-q24.32      Physical location : 120.759.914 - 120.765.592
Synonym symbol(s) PLA2, PLA2A, PPLA2
EC.number 3.1.1.4
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion secreted
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
14 cysteine residues, forming seven disulfide bonds
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • phospholipase A2, Ca2+ dependent, group 1B, inducing cell proliferation, smooth muscle contraction and lipid mediator release
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other cleaved by caspase 1 and caspase 8,for proteolysis and inactivation during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility to obesity
    Variant & Polymorphism SNP increasing the risk of obesity
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS