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FLASH GENE
Symbol PLA2G10 contributors: - updated : 18-05-2006
HGNC name phospholipase A2, group X
HGNC id 9029
Location 16p13.1-p12      Physical location : 14.766.406 - 14.788.526
Synonym name phosphatidycholine 2-acylhydrolase
Synonym symbol(s) PLA2GX, SPLA2, GXPLA2, GXSPLA2
EC.number 3.1.1.4
DNA
TYPE functioning gene
STRUCTURE 22.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 1020 18 165 - Cupillard
- - - 800 - - pancreas, lung, colon Cupillard
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon lowly
 pancreas exocrine   lowly
 stomach   moderately
Lymphoid/Immunespleen    
 thymus    
Nervousbrain   lowly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • sixteen cysteine residues forming eight disulfide bonds
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Pla2g10 (72.2pc)
    homolog to rattus Pla2g10 (70.8pc)
    Homologene
    FAMILY phosphoplipase A2 family
    CATEGORY enzyme , immunity/defense , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having a powerful potency for releasing arachidonic acid from cell membrane phospholipids
  • catalyzing the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
  • playing a potential role in neuronal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • lipid catabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Ca2+ (one ion per subunit)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS