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FLASH GENE
Symbol PLA2G10 contributors: - updated : 18-05-2006
HGNC name phospholipase A2, group X
HGNC id 9029
Location 16p13.1-p12      Physical location : 14.766.406 - 14.788.526
Synonym name phosphatidycholine 2-acylhydrolase
Synonym symbol(s) PLA2GX, SPLA2, GXPLA2, GXSPLA2
EC.number 3.1.1.4
DNA
TYPE functioning gene
STRUCTURE 22.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC388213 16 LOC388213 FLJ11151 16p13.13 hypothetical protein FLJ11151 LOC390675 16 similar to TATA element modulatory factor 1 ERCC4 16p13.13 excision repair cross-complementing rodent repair deficiency, complementation group 4 MRTF-B 16p13.13 myocardin-related transcription factor B CGI-148P 16p13 CGI-148 protein pseudogene LOC388214 16 LOC388214 PARN 16p13 poly(A)-specific ribonuclease (deadenylation nuclease) BFAR 16p13.2 bifunctional apoptosis regulator PLA2G10 16p13.1-p12 phospholipase A2, group X PKD1P3 16p13.3 phospholipase A2, group X NPIP 16q13.1 nuclear pore complex interacting protein LOC123803 RRN3 16p12 RNA polymerase I transcription factor RRN3 PKD1P6 16p13.3 RNA polymerase I transcription factor RRN3 LOC388215 16 similar to hypothetical protein LOC339047 FLJ39599 16p13.13 hypothetical protein FLJ39599 BC008967 16p13.13 hypothetical gene BC008967 LOC388216 16 LOC388216 LKAP 16p13.13 limkain b1 NDE1 16p13.11 nudE nuclear distribution gene E homolog 1 (A. nidulans) MYH11 16p13.12 myosin, heavy polypeptide 11, smooth muscle FLJ31153 16p13.13-p13.12 hypothetical protein FLJ31153 LOC390676 16 similar to 60S ribosomal protein L15 ABCC1 16p13.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 ABCC6 16p13.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 LOC339041 16p13.12 hypothetical LOC339041 PKD1P1 16p13.3 hypothetical LOC339041 PKD1P2 16p13.3 hypothetical LOC339041 LOC390677 16 similar to hypothetical protein FLJ21415
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 1020 18 165 - Cupillard
- - - 800 - - pancreas, lung, colon Cupillard
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon lowly
 pancreas exocrine   lowly
 stomach   moderately
Lymphoid/Immunespleen    
 thymus    
Nervousbrain   lowly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • sixteen cysteine residues forming eight disulfide bonds
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Pla2g10 (72.2pc)
    homolog to rattus Pla2g10 (70.8pc)
    Homologene
    FAMILY phosphoplipase A2 family
    CATEGORY enzyme , immunity/defense , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • having a powerful potency for releasing arachidonic acid from cell membrane phospholipids
  • catalyzing the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
  • playing a potential role in neuronal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • lipid catabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Ca2+ (one ion per subunit)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS