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FLASH GENE
Symbol PKP4 contributors: mct - updated : 27-09-2017
HGNC name plakophilin 4
HGNC id 9026
Location 2q24.1      Physical location : 159.313.475 - 159.537.938
Synonym name catenin 4
Synonym symbol(s) p0071, ARMRP, FLJ31261, FLJ42243
DNA
TYPE functioning gene
STRUCTURE 224.55 kb     22 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
NR4A2 2q22-q23 nuclear receptor subfamily 4, group A, member 2 LOC389055 2 LOC389055 GPD2 2q24.1 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) LOC391455 2 similar to Acidic ribosomal phosphoprotein P0 LOC220786 2q24.2 cyclin-dependent kinase 7 pseudogene GALNT5 2q24.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) KIAA1189 2q24.2 KIAA1189 protein PSCDBP 2q11.2 pleckstrin homology, Sec7 and coiled-coil domains, binding protein ACVR1C 2q24-q31 activin A receptor, type IC ACVR1 2q23-q24 activin A receptor, type I UPP2 2q24.2 uridine phosphorylase 2 LOC130940 2q24.2 hypothetical protein BC015395 PKP4 2q23-q31 Plakophilin 4 LOC391456 2 similar to KIAA0181 LOC92196 2q24.2 similar to death-associated protein OR7E89P 2q31.3 olfactory receptor, family 7, subfamily E, member 89 pseudogene LOC391457 2 similar to putative taste receptor HTR2 OR7E90P 2q31.3 olfactory receptor, family 7, subfamily E, member 90 pseudogene MGC23908 2 similar to RNA polymerase B transcription factor 3 KIAA1728 2q24.2 KIAA1728 protein FLJ36175 2q24.2 hypothetical protein FLJ36175 BAZ2B 2q23-q24 bromodomain adjacent to zinc finger domain, 2B AXOT 2q24.2 axotrophin DCL-1 2q24.2 type I transmembrane C-type lectin receptor DCL-1 LY75 2p24 lymphocyte antigen 75 PLA2R1 2q23-q24.1 phospholipase A2 receptor 1, 180kDa ITGB6 2q24-q31 integrin, beta 6 RBMS1 2q24.2 RNA binding motif, single stranded interacting protein 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
22 splicing 4690 131.7 1192 - 2014 24163434
21 splicing 4561 127 1149 - 2014 24163434
  • lacking an alternate in-frame exon compared to variant 1
  • 22 - 4687 - 1191 - 2014 24163434
    22 - 4610 - 849 - 2014 24163434
    16 - 3184 - 913 - 2014 24163434
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Hearing/Equilibriumear   predominantly
    Nervousbrain   moderately
     nerve   moderately
    Reproductivefemale systembreastmammary gland moderately
     female systemuteruscervix moderately
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   moderately
     kidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine ARM repeats
  • a conserved central domain consisting of a series of repeated motifs, the armadillo repeats, which is flanked by more diverse N- and C-terminal domains
  • HOMOLOGY
    interspecies homolog to rattus Pkp4 (96.6 pc)
    homolog to murine Pkp4 (96.6 pc)
    Homologene
    FAMILY
  • Armadillo proteins family
  • p120 catenin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    plasma membrane,junction,desmosome
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • myofibrils
  • colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells
  • localized as a plaque protein in adhaerens junctions (AJs) of diverse epithelia and certain vascular endothelia, in the composite junctions (areal compositae) of the intercalated disks of cardiomyocytes
  • junctional plaque component involved in cell-cell adhesion, especially in adherens junctions
  • basic FUNCTION
  • regulating functional plaque organization and cadherin function
  • playing an essential role in spatially regulating restricted Rho signalling during cytokinesis
  • armadillo protein that is localized at the midbody during cytokinesis and is essential for cell division
  • plays a role in cytokinesis, in which it regulates local activation of RHOA together with ECT2
  • PKP4 and ECT2 are transported via distinct motors, identifying a novel pathway implicating KIF3B in the regulation of actin organization during cytokinesis
  • is an intercellular junction protein of the p120 catenin family
  • has likely a key role in regulating recycling through the RAB11A-dependent perinuclear recycling compartment, and links the regulation of adherens junctions to recycling to allow dynamic modulation of intercellular adhesion
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PDZD2
  • full activation of RHOA required ECT2 as well as PKP4 indicating that these two proteins act in conjunction to regulate RHOA during cytokinesis
  • PKP4 is a potential novel FLCN interacting protein
  • is an important and novel FMR1 target, strongly suggesting that impaired actin cytoskeletal functions mediated by an excess of PKP4 are key aspects underlying the fragile X syndrome
  • RAB11A is a novel interaction partner of PKP4
  • directly interacts with the KIF3/subunit KIF3B, and also interacts with the kinesin cargo adaptor protein KIFAP3 acting as a stabilizing linker between KIF3B and its KIFAP3 cargo binding entity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS