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FLASH GENE
Symbol PKNOX2 contributors: - updated : 20-06-2006
HGNC name PBX/knotted 1 homeobox 2
HGNC id 16714
Location 11q24      Physical location : 125.034.558 - 125.303.283
Synonym symbol(s) PREP2, FLJ13074
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 81.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC390272 11 similar to seven transmembrane helix receptor LOC283162 11q24.2 similar to Olfactory receptor 8B4 OR8B8 11q24.2 olfactory receptor, family 8, subfamily B, member 8 LOC390273 11 similar to Olfactory receptor 8A1 (OST025) OR8B9P 11q25 olfactory receptor, family 8, subfamily B, member 9 pseudogene LOC390274 11 similar to olfactory receptor MOR161-5 LOC219858 11q24.2 similar to Olfactory receptor 8B12 LOC390275 11 similar to Olfactory receptor 8A1 (OST025) PANX3 11q24.2 pannexin 3 TBRG1 11q24.2 likely ortholog of mouse transforming growth factor beta regulated gene 1 CSE-C 11q24 cytosolic sialic acid 9-O-acetylesterase homolog SPA17 11q24.2 sperm autoantigenic protein 17 NRGN 11q24 neurogranin (protein kinase C substrate, RC3) CTXL 11q24 cortical thymocyte receptor (X. laevis CTX) like ESAM 11q24.2 cortical thymocyte receptor (X. laevis CTX) like FLJ23342 11q24.2 hypothetical protein FLJ23342 RBIG1 11q24.2 retinoblastoma inhibiting gene 1 ROBO4 11q24.2 roundabout homolog 4, magic roundabout (Drosophila) FLJ25530 11q24.2 hypothetical protein FLJ25530 FLJ13215 11q24.2 hypothetical protein FLJ13215 LOC387816 11 similar to hypothetical protein SLC37A2 11q24.2 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 LOC219854 11q24.2 hypothetical protein LOC219854 LOC390276 11 hypothetical gene supported by AK128036 LOC387817 11 LOC387817 PKNOX2 11q24 PBX/knotted 1 homeobox 2 FLJ30719 11q24.2 hypothetical protein FLJ30719 FEZ1 11q23.3-q24.2 fasciculation and elongation protein zeta 1 (zygin I) EI24 11q23-q24 etoposide induced 2.4 mRNA ITM1 11q23.3-q24.2 integral membrane protein 1 CHEK1 11q24 CHK1 checkpoint homolog (S. pombe) ACRV1 11p12-q13 acrosomal vesicle protein 1 PATE 11q24.2 acrosomal vesicle protein 1 FLJ32915 11q24.2 hypothetical protein FLJ32915 FKSG32 11q24.2 hypothetical protein FKSG32 DDX25 11q24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 LOC338667 11q24.2 hypothetical protein LOC338667 CDON 11q23-q24 cell adhesion molecule-related/down-regulated by oncogenes LOC387818 11 similar to Nucleosome assembly protein 1-like 1 (NAP-1 related protein) (hNRP) LOC387819 11 LOC387819
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Nervousbrain   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
intraspecies homolog to PREP1
Homologene
FAMILY
  • TALE (three amino acid loop extension) class of homeodomain-containing transcription factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text colocalizes with both the actin and microtubule cytoskeletons
    basic FUNCTION
  • playing a role in tissue -specific regulation of transcription
  • transcriptional regulator (action modulated through the subcellular distribution of multiple isoforms and by interaction with two distinct cytoskeletal systems)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimer with PBX1
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with PBX in apparently non-HOX-dependent cooperative DNA binding as well
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS