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FLASH GENE
Symbol PKN2 contributors: mct - updated : 13-06-2017
HGNC name protein kinase N2
HGNC id 9406
Location 1p22.2      Physical location : 89.149.921 - 89.301.937
Synonym name
  • PAK2, rat homolog of
  • protein kinase C-like 2
  • Synonym symbol(s) PRK2, PAK2, PKL2, PRKCL2, MGC71074
    EC.number 2.7.1.37/ 2.7.11.13
    DNA
    TYPE functioning gene
    STRUCTURE 152.11 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 6199 - 984 - 1997 9121475
    21 - 6055 - 936 - 1997 9121475
    22 - 6151 - 968 - 1997 9121475
    21 - 6898 - 827 - 1997 9121475
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Lymphoid/Immunelymph node    
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
     kidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines DX3 B cell myeloma cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region of PKN1, PKN2, PKN3 plays a role in their regulation, and also contains three Rho-binding domains (HR1a, HR1b, and HR1c), mediating an intermolecular PKN2-PKN2 interaction
  • one C2-like domain and the catalytic domain of PKN2 are separated by a linker of 195 amino acids
  • three REM (Hr1) repeats
  • serine/threonine kinase domain found in the C-terminal region of the protein that shows high sequence homology to other members of the PKC superfamily , and activating C-terminal PIF sequence displaces the binding of the inhibitory N-terminal PKL sequence with extreme C-terminal segment critical for the full activation of PKN2 by RHOA in cells in a GTP-dependent manner
  • HOMOLOGY
    interspecies homolog to C.elegans F46f6.2
    ortholog to murine Pkn2
    Homologene
    FAMILY
  • protein kinase N (PKN) family
  • PKC subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • protein serine/threonine kinase activity
  • the C-terminal PRK2 fragment (naturally generated during apoptosis) acts as a potent negative regulator of PDK1 autophosphorylation and PDK1 kinase activity against PKC-zeta and -delta
  • the C-terminal fragment strongly inhibits the AKT1-mediated phosphorylation of BAD, a pro-apoptotic BCL2 family protein, and blocks the anti-apoptotic activities of AKT1
  • is involved in actin cytoskeletal organization, keratinocyte cell-cell adhesion, and differentiation, mainly through activation by Rho GTPases
  • is required for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of CDC25B, the phosphatase required for activation of mitotic cyclin/CDK1 complexes at the G2/M transition
  • is recruited to nascent cell-cell contacts through its C2-like and Rho-binding domains and promotes junctional maturation through a kinase-dependent pathway
  • has a critical role in the migration and invasion of tumor cells
  • is the host kinase that phosphorylates the hepatitis C virus RNA polymerase
  • is implicated in regulation of various biological processes, including cell migration, adhesion and death
  • has a critical role in cell adhesion-mediated AKT1 activation during myoblast differentiation
  • PKN2 has likely distinct nonredundant functions with PKN1, PKN3, despite the structural similarity and evolutionary relationship among the three isoforms
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • PTPN13 for regulation of the action cytoskeleton
  • RHO binding is essential for PNK2 function and also facilitates PNK2 recruitment to junctions
  • HSP90AA1 plays a critical role in the regulation of HCV RNA polymerase phosphorylation via the PDK1-PKN2 signaling pathway
  • interact with and inhibit AKT1 thereby inducing cell death
  • CDK10 is a protein kinase that partners with cyclin M to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth
  • cell & other
    REGULATION
    activated by lipids and limited proteolysis with trypsin
    Other autophosphorylated
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS