basic FUNCTION
| protein serine/threonine kinase activity |
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the C-terminal PRK2 fragment (naturally generated during apoptosis) acts as a potent negative regulator of PDK1 autophosphorylation and PDK1 kinase activity against PKC-zeta and -delta |
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the C-terminal fragment strongly inhibits the AKT1-mediated phosphorylation of BAD, a pro-apoptotic BCL2 family protein, and blocks the anti-apoptotic activities of AKT1 |
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is involved in actin cytoskeletal organization, keratinocyte cell-cell adhesion, and differentiation, mainly through activation by Rho GTPases |
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is required for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of CDC25B, the phosphatase required for activation of mitotic cyclin/CDK1 complexes at the G2/M transition |
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is recruited to nascent cell-cell contacts through its C2-like and Rho-binding domains and promotes junctional maturation through a kinase-dependent pathway |
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has a critical role in the migration and invasion of tumor cells |
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is the host kinase that phosphorylates the hepatitis C virus RNA polymerase |
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is implicated in regulation of various biological processes, including cell migration, adhesion and death |
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has a critical role in cell adhesion-mediated AKT1 activation during myoblast differentiation |
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PKN2 has likely distinct nonredundant functions with PKN1, PKN3, despite the structural similarity and evolutionary relationship among the three isoforms |