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FLASH GENE
Symbol PKN1 contributors: mct - updated : 13-06-2014
HGNC name protein kinase N1
HGNC id 9405
Location 19p13.12      Physical location : 14.544.165 - 14.582.678
Synonym name
  • serine/threonine kinase N
  • protein kinase C-like 1
  • protein kinase PKN-alpha
  • Synonym symbol(s) PKN, DBK, PAK1, PRK1, PRKCL1, MGC46204
    EC.number 2.7.1.37, 2.7.11.13
    DNA
    TYPE functioning gene
    STRUCTURE 38.51 kb     22 Exon(s)
    MAPPING cloned Y linked   status provisional
    Map pter - D19S221 - D19S226 - PKN1 - D19S930
    Authors Bartsch (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 2964 - 948 - 1998 9570957
    22 - 3097 104 942 - 1998 9570957
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivesalivary gland   highly
    Endocrinepancreas    
    Lymphoid/Immunetonsils   highly
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal leucine-zipper-like domain, and three tandem HR1 domains (the second HR1 domain plays a role in binding to RHOA), and N-terminal region of PKN1, PKN2, PKN3 plays a role in their regulation
  • a catalytic domain typical of the PRK family
  • TRAF2-binding consensus sequences PXQX (S/T) at amino acid residues 580-584 (PIQES)
  • HOMOLOGY
    interspecies homolog to murine Prkcl1
    homolog to C.elegans f46f6.2
    Homologene
    FAMILY
  • serine/threonine kinase family
  • protein kinase C superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinase involved in the regulation of cell motility
  • involved in TRAF2-NF-kappaB signaling pathway
  • neurofilament head/rod domain kinase that may contribute to the pathogenic process in ALS
  • plays a critical role in regulating constitutive IKK/JNK activity in unstimulated cells
  • involved in TRAF1 phosphorylation, thereby playing a critical role in the negative regulation of tonic activity of the two central inflammatory signaling pathways
  • role in ovarian cancer development or progression
  • stress-activated protein kinase, mediating phosphorylation of alpha B crystallin and stimulation of proteasome activity, which, in part, mediates the protective effect of PKN1 in the heart
  • PKN1 and PKN3 phosphorylate serine residues in sequence contexts that have an arginine residue in position -3
  • neuroprotective role of PKN1 in hypoxia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    actication of JUN kinase
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDK1 (phosphoinositide-dependent protein kinase 1)
  • interacting with TRAF2, directly binding to the TRAF domain of TRAF2
  • TRAF1 is a substrate of PKN1 kinase activity, and the phosphorylation event is required for attenuating downstream kinase activities
  • cell & other
    REGULATION
    activated by fatty acid and Rho and limited proteolysis with trypsin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS