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FLASH GENE
Symbol PKMYT1 contributors: mct - updated : 29-09-2010
HGNC name protein kinase, membrane associated tyrosine/threonine 1
HGNC id 29650
Location 16p13.3      Physical location : 3.022.793 - 3.030.474
Synonym name
  • membrane-associated tyrosine- and threonine specific cdc2-inhibitory kinase
  • Myt1 kinase
  • Synonym symbol(s) MYT1, DKFZp547K1610, FLJ20093
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 7.68 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KCTD5 16p13.3 potassium channel tetramerisation domain containing 5 MPN 16p13.3 pancreasin SRRM2 16p13.3 serine/arginine repetitive matrix 2 TCEB2 13q12.1 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) LOC246718 16p12.3 ranscription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene EOS 16p13.3 serine protease EOS TESSP1  testis serine protease 1 PRSS21 16p13.3 protease, serine, 21 (testisin) LOC124220 16p13.3 similar to common salivary protein 1 MGC52282 16p13.3 hypothetical protein MGC52282 PRSS22 16p13.3 protease, serine, 22 LOC114984 16p13.3 hypothetical protein BC014089 DKFZp761A132 16p13.3 hypothetical protein DKFZp761A132 FLJ30002 16p13.3 hypothetical protein FLJ30002 KREMEN2 16p13.3 kringle containing transmembrane protein 2 PKMYT1 16p13.3 kringle containing transmembrane protein 2 LOC388205 16 similar to RIKEN cDNA 1520401A03 gene LOC388206 16 LOC388206 CLDN9 16p13.3 claudin 9 CLDN6 16p13.3 claudin 6 TNFRSF12A 16p13.3 tumor necrosis factor receptor superfamily, member 12A HCFC1R1 16p13.3 host cell factor C1 regulator 1 (XPO1 dependant) MGC2655 16p13.3 hypothetical protein MGC2655 LOC146439 16p13.3 similar to CDNA sequence BC038613 MMP25 16p13.3 matrix metalloproteinase 25 MMPL1 16p13.3 matrix metalloproteinase-like 1 NK4 16p13.3 matrix metalloproteinase-like 1 ZNF206 16p13.3 zinc finger protein 206 MGC3771 16p13.3 hypothetical protein MGC3771 ZNF205 16p13.3 zinc finger protein 205 ZNF213 16p13.3 zinc finger protein 213 LOC197350 16p13.3 hypothetical protein LOC197350 OR1F1 16p13.3 olfactory receptor, family 1, subfamily F, member 1 OR1F2 16p13.3 olfactory receptor, family 1, subfamily F, member 2 ZNF200 16p13.3 zinc finger protein 200 MEFV 16p13.3 Mediterranean fever
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2121 55 499 - PMID: 10504341
    9 - 2159 55 499 - PMID: 10504341
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase, M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a tyrosine-serine
  • threonine dual specificity tyrosine kinase catalytic domain
  • C-terminal domain required for recruitment of CDK1, and this domain potentially lies in the cytoplasm because it can interact with and is phosphorylated by CDC
  • HOMOLOGY
    interspecies ortholog to Myt1Xe Xenopus laevis
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • WEE1 subfamily
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleoplasm
    text membrane associated
    basic FUNCTION
  • inhibitory kinase, negative regulator of the G2/M transition
  • its catalytic activity was not essential for the cell cycle delay observed with human cells
  • can negatively regulate CDK1/CCNB1 and inhibit G(2)/M progression by two means, both of which require the C-terminal domain (first, can bind and sequester CDK1/CCNB1 in the cytoplasm preventing entry into the nucleus, and, second, it can phosphorylate associated CDK1/CCNB1 at Thr14 and Tyr15 thus inhibiting its catalytic activity)
  • dual-specificity kinase that contributes to the regulation of the cell cycle by adding inhibitory phosphates to the cyclin-dependent kinases (Cdk/cyclins)
  • may be playing a key role in the G2 arrest of oocytes
  • inhibitory kinase for CDK1, the master engine of mitosis, and has been thought to function, together with WEE1, as a negative regulator of mitotic entry
  • essential role for Golgi and ER assembly during mitotic exit
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylating and inhibiting CDC2
  • interacting with STEAP3
  • mediates MAP2K1 effects on the Golgi complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    with Wee1 induced the phosphorylation of CDC2 leading to G2/M arrest
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS