protein
| binds directly and selectively to tyrosine-phosphorylated peptides |
|
OPA protein |
|
interacting with HNRNPA2B1, PTBP1, and HNRNPA1 (have critical role in promoting PKM2 production in tumours, and overexpression of some combination of them is, like PKM2 expression, likely to be a general phenomenon in cancer  |
|
interaction with PKM2, and inhibition of PKM2 by PRL contributes potentially to the PRL-stimulated cell proliferation  |
|
SAICAR stimulates PKM and promotes cancer cell survival in glucose-limited conditions  |
|
KDM8/PKM interaction resides at the intersubunit interface region of PKM, which hinders PKM tetramerization and blocks pyruvate kinase activity  |
|
ZBTB7A directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM  |
|
TRIM35 interacts with PKM and the coiled-coil domain is required for such an interaction  |
|
ECM1 plays an important role in promoting the Warburg effect mediated by PKM  |
|
TRIM35 inhibits phosphorylation of pyruvate kinase isoform M2 (PKM), which is involved in aerobic glycolysis of cancer cells  |
|
TGM2 interacts with PKM, a rate limiting enzyme of glycolysis which is responsible for maintaining a glycolytic phenotype in malignant cells and displays non metabolic functions, including transcriptional co-activation and protein kinase activity  |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in gastric cancer | tumoral
|  
|  
| --over
|  
|
with MYC, PTBP1, HNRNPA1 and HNRNPA2B1 in gliomas, correlated with PKM2 expression  | tumoral
|  
|  
| --over
|  
|
in a grade-specific manner in human glioma  | |