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FLASH GENE
Symbol PKIG contributors: mlc - updated : 14-12-2007
HGNC name protein kinase (cAMP-dependent, catalytic) inhibitor gamma
HGNC id 9019
Location 20q12-q13.1      Physical location : 43.160.435 - 43.247.677
Synonym name PKI-gamma
Synonym symbol(s) MGC126458, MGC126459
DNA
TYPE functioning gene
SPECIAL FEATURE
text maybe tightly linked to ADA, tail to tail as in the mouse
STRUCTURE 87.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D20S596 - PKIG - D20S169 - YWHAB - D20S119 - qter
Authors Gene Map (98)
Physical map
SGK2 20q13.2 serum/glucocorticoid regulated kinase 2 C20orf9 20q12-q13.1 chromosome 20 open reading frame 9 RPL27AP 20q13.11 ribosomal protein L27a pseudogene MYBL2 20q13.1 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 C20orf65 20q13.11 chromosome 20 open reading frame 65 C20orf100 20q13.11 chromosome 20 open reading frame 100 JPH2 20q12-q13.1 junctophilin 2 C20orf111 20q13.11 chromosome 20 open reading frame 111 GDAP1L1 20q12 ganglioside-induced differentiation-associated protein 1-like 1 C20orf142 20q13.12 chromosome 20 open reading frame 142 R3HDML 20 R3H domain (binds single-stranded nucleic acids) containing-like FLJ39654 20q13.12 hypothetical protein FLJ39654 LOC149704 20q13.12 hypothetical LOC149704 HNF4A 20q12-q13.1 hepatocyte nuclear factor 4, alpha RPL37AP1 20q12 ribosomal protein L37a pseudogene 1 C20orf121 20q13.11 chromosome 20 open reading frame 121 TDE1 20q13.1-q13.3 tumor differentially expressed 1 PKIG 20q13.2-q13.13 protein kinase (cAMP-dependent, catalytic) inhibitor gamma ADA 20q12 adenosine deaminase MGC5566 20q13.12 hypothetical protein MGC5566 WISP2 20q12-q13.1 WNT1 inducible signaling pathway protein 2 KCNK15 20q12-q13 potassium channel, subfamily K, member 15 RIMS4 20 regulating synaptic membrane exocytosis 4 LOC391252 20 similar to piggyBac transposable element derived 4 YWHAB 20q13.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide LOC200226 20q13.12 similar to Polyadenylate-binding protein 2 (Poly(A)-binding protein 2) (PABP 2) TOMM34 20q12-q13.11 translocase of outer mitochondrial membrane 34 STK4 20q11.2-q13.2 serine/threonine kinase 4 KCNS1 20q12 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 WFDC5 20q13.11 WAP four-disulfide core domain 5 WFDC12 20q12-q13.1 WAP four-disulfide core domain 12 PI3 20q12-q13 protease inhibitor 3, skin-derived (SKALP) SEMG1 20q13.1 semenogelin I SEMG2 20q13.1 semenogelin II LOC149709 20q13.12 similar to RIKEN cDNA 1700049M11 SLPI 20q12-q13.2 secretory leukocyte protease inhibitor (antileukoproteinase) MATN4 20q13.1-q13.2 matrilin 4 RBPSUHL 20q12-q13.1 recombining binding protein suppressor of hairless (Drosophila)-like SDC4 20q13.1 syndecan 4 (amphiglycan, ryudocan) C20orf35 20q13.12 chromosome 20 open reading frame 35 C20orf10 20q12-13.12 chromosome 20 open reading frame 10 PIGT 20q12-q13.1 phosphatidyl inositol glycan class T
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1458 - 76 - Ewing (2007)
4 - 1206 - 76 - Ewing (2007)
5 - 1353 - 76 - Ewing (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivesalivary gland   highly
Endocrineparathyroid   highly
Lymphoid/Immunetonsils   highly
Reproductivemale systemtestis   
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal inhibitory region that includes a pseudosubstrate sequence
  • a central region containing a leucine and hydrophobic aminoacid rich nuclear export sequence
  • a non conserved C terminus
    • HOMOLOGY
    Homologene
    FAMILY cAMP-dependent protein kinase (PKA) inhibitor family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as a potent competitive PKA inhibitor
  • extremely potent competitive inhibitor of cAMP-dependent protein kinase activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with BMP2 (activation of the PKA pathway may be one of key BMP2-activated signaling events that lead to osteogenesis and downregulation of PKIG may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS