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FLASH GENE

Symbol

PKIG

contributors: mlc - updated : 14-12-2007

HGNC name	protein kinase (cAMP-dependent, catalytic) inhibitor gamma
HGNC id	9019

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q12-q13.1      Physical location : 43.160.435 - 43.247.677
Synonym name	PKI-gamma
Synonym symbol(s)	MGC126458, MGC126459

DNA

TYPE	functioning gene
SPECIAL FEATURE
text	maybe tightly linked to ADA, tail to tail as in the mouse
STRUCTURE	87.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	cen - D20S596 - PKIG - D20S169 - YWHAB - D20S119 - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 1458 - 76 - Ewing (2007) variant 2 4 - 1206 - 76 - Ewing (2007) variant 3 5 - 1353 - 76 - Ewing (2007)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive salivary gland       highly Endocrine parathyroid       highly Lymphoid/Immune tonsils       highly Reproductive male system testis       Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal inhibitory region that includes a pseudosubstrate sequence
	a central region containing a leucine and hydrophobic aminoacid rich nuclear export sequence
	a non conserved C terminus

HOMOLOGY

Homologene

FAMILY

cAMP-dependent protein kinase (PKA) inhibitor family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	acting as a potent competitive PKA inhibitor
	extremely potent competitive inhibitor of cAMP-dependent protein kinase activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with BMP2 (activation of the PKA pathway may be one of key BMP2-activated signaling events that lead to osteogenesis and downregulation of PKIG may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS