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FLASH GENE
Symbol PKIG contributors: mlc - updated : 14-12-2007
HGNC name protein kinase (cAMP-dependent, catalytic) inhibitor gamma
HGNC id 9019
Location 20q12-q13.1      Physical location : 43.160.435 - 43.247.677
Synonym name PKI-gamma
Synonym symbol(s) MGC126458, MGC126459
DNA
TYPE functioning gene
SPECIAL FEATURE
text maybe tightly linked to ADA, tail to tail as in the mouse
STRUCTURE 87.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D20S596 - PKIG - D20S169 - YWHAB - D20S119 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1458 - 76 - Ewing (2007)
4 - 1206 - 76 - Ewing (2007)
5 - 1353 - 76 - Ewing (2007)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivesalivary gland   highly
Endocrineparathyroid   highly
Lymphoid/Immunetonsils   highly
Reproductivemale systemtestis   
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal inhibitory region that includes a pseudosubstrate sequence
  • a central region containing a leucine and hydrophobic aminoacid rich nuclear export sequence
  • a non conserved C terminus
  • HOMOLOGY
    Homologene
    FAMILY cAMP-dependent protein kinase (PKA) inhibitor family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as a potent competitive PKA inhibitor
  • extremely potent competitive inhibitor of cAMP-dependent protein kinase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with BMP2 (activation of the PKA pathway may be one of key BMP2-activated signaling events that lead to osteogenesis and downregulation of PKIG may be prerequisite for the PKA activation during the osteoblastic differentiation of precursor cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS