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FLASH GENE
Symbol PKIB contributors: npt - updated : 19-11-2005
HGNC name protein kinase (cAMP-dependent, catalytic) inhibitor beta
HGNC id 9018
Location 6q22.32      Physical location : 122.793.061 - 123.047.517
Synonym name cAMP-dependent protein kinase inhibitor beta
Synonym symbol(s) PRKACN2, IPKB, PKI-beta, FLJ23817
DNA
TYPE functioning gene
STRUCTURE 254.40 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text variants 1, 2, 3 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1905 8.5 78 brain, placenta Zheng
- - 1909 8.5 78 brain, placenta, heart, liver, pancreas Zheng
- - 1842 8.5 78 - Zheng
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta, primitive neurectoderm
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Pkib
Homologene
FAMILY
  • PKI family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • potent competitive inhibitor of C- AMP-dependent protein kinase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS