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FLASH GENE
Symbol PKIA contributors: - updated : 29-07-2004
HGNC name protein kinase (cAMP-dependent, catalytic) inhibitor alpha
HGNC id 9017
Location 8q21.11-q21..133      Physical location : 79.428.335 - 79.515.484
Synonym symbol(s) PRKACN1
DNA
TYPE functioning gene
STRUCTURE 87.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D8S526 - IL7 ,PKIA - D8S1736 - D8S275 - qter
Authors GeneMap
Physical map
LOC83690 8q13.3 CocoaCrisp LOC389670 8 hypothetical gene supported by BC062758 LOC392234 8 similar to Pyruvate kinase, M2 isozyme HNF4G 8q21.3-q22.1 hepatocyte nuclear factor 4, gamma MRPL9P1 8q21.11 mitochondrial ribosomal protein L9 pseudogene ZFH4 8q13.3 mitochondrial ribosomal protein L9 pseudogene PXMP3 8q21.1 peroxisomal membrane protein 3, 35kDa (Zellweger syndrome) PKIA 8q13-q21.3 protein kinase (cAMP-dependent, catalytic) inhibitor alpha CGI-62 8q21.11 CGI-62 protein IL7 8q12-q13 interleukin 7 STMN2 8p13.2 stathmin-like 2 HEY1 8q21 hairy/enhancer-of-split related with YRPW motif 1 MRPS28 8q21.1-q21.2 mitochondrial ribosomal protein S28 TPD52 8q21 tumor protein D52 LOC389671 8 LOC389671 LOC392236 8 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC340443 8q21.12 similar to ribosomal protein S5; 40S ribosomal protein S5 RINZF LOC389672 8 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC392237 8 similar to mitochondrial carrier triple repeat 1 CKS1A 8q21 CDC28 protein kinase regulatory subunit 1A PAG 8q21.13 CDC28 protein kinase regulatory subunit 1A LOC392238 8 LOC392238 LOC392239 FABP5 15q12-q24.3 fatty acid binding protein 5 (psoriasis-associated) PMP2 8q21.3-q22.1 peripheral myelin protein 2 FABP4 8q21 fatty acid binding protein 4, adipocyte LOC389673 8 similar to Myelin P2 protein LOC392240 8 similar to hypothetical protein MGC5466 IMPA1 8q21.2-q21.3 inositol(myo)-1(or 4)-monophosphatase 1 FLJ14007 8q21.13 hypothetical protein FLJ14007 Shax3 8q21.13 Snf7 homologue associated with Alix 3 SNX16 8q21.13 sorting nexin 16
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2184 - 76 heart Zheng,Olsen
- splicing 2055 - 76 skeletal muscle Zheng,Olsen
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunespleen    
Nervousbrain    
Reproductivemale systemtestis   
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY cAMP-dependent protein kinase (PKA) inhibitor family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • protein kinase (CAMP-dependent,catalytic) inhibitor alpha, may be involved in negative regulation of protein kinase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS