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FLASH GENE
Symbol PJA2 contributors: mct - updated : 18-01-2013
HGNC name praja 2, RING-H2 motif containing
HGNC id 17481
Location 5q21.3      Physical location : 108.670.410 - 108.745.675
Genatlas name praja 2
Synonym name
  • related to rabbit neuro DAP1, >100kDa, cytoplasmic
  • praja 2, RING-H2 motif containing
  • ring finger protein 131
  • Synonym symbol(s) NEURODAP1, KIAA0438, RNF131, PRAJA2
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 75.27 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC345571 5q21.3 similar to rap2 interacting protein x LOC391817 5 similar to protease (prosome, macropain) 26S subunit, ATPase 1 EFNA5 5q21 ephrin-A5 LOC391818 5 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) LOC345576 5q21.3 similar to Ubiquitin carboxyl-terminal hydrolase 7 (Ubiquitin thiolesterase 7) (Ubiquitin-specific processing protease 7) (Deubiquitinating enzyme 7) (Herpesvirus associated ubiquitin-specific protease) FBXO13 5q21.3 F-box only protein 13 RPS20P3 5q13-q23 ribosomal protein S20 pseudogene 3 FER 5q21 fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) GJA1P1 5q21.3 gap junction protein, alpha 1, 43kDa (connexin 43) pseudogene 1 PJA2 5q21.1 praja 2, RING-H2 motif containing LOC391819 5 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) MAN2A1 5q21-q22 mannosidase, alpha, class 2A, member 1 LOC153778 5q22.1 hypothetical LOC153778 LOC255338 5q22.1 hypothetical LOC255338 LOC91137 5q22.2 hypothetical protein BC017169 LOC134433 5q22.2 similar to Zinc finger DHHC domain containing protein 8 (Zinc finger protein 378) LOC285639 5q22.2 similar to Bcl-2-associated transcription factor TSLP 5q22.2 thymic stromal lymphopoietin TA-WDRP 5q22.2 T-cell activation WD repeat protein LOC133744 5q22.2 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 CAMK4 5q21-q23 calcium/calmodulin-dependent protein kinase IV STARD4 5q21.3 START domain containing 4, sterol regulated C5orf13 5q22.1 chromosome 5 open reading frame 13 TIGA1 5q21-q22 TIGA1 EPB41L4A 5q22.1 erythrocyte membrane protein band 4.1 like 4A FLJ11235 5q22.2 hypothetical protein FLJ11235 APC 5q21-q22 adenomatosis polyposis coli SRP19 5q21 signal recognition particle 19kDa DP1 5q22-q23 polyposis locus protein 1 XBPP1 5q14.3-q15 X-box binding protein pseudogene 1 U2AF1L1 5q22 U2(RNU2) small nuclear RNA auxillary factor 1-like 1 DCP2 5q22.3 decapping enzyme hDcp2 MCC 5q21 mutated in colorectal cancers
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4878 - 708 - 2006 16247473
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    RING-H2 zinc finger domain
    HOMOLOGY
    interspecies homolog to rabbit neuro DAP1
    intraspecies homolog to PJA1
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • postsynaptic density of axosomatic synapse
  • cytoplasmic side of the membrane
  • basic FUNCTION
  • control of post-synaptic density (PSD) for maintaining the function of neurons
  • RING ligase that controls the stability of PRKACA regulatory (R) subunits
  • required for efficient nuclear cAMP signalling and for PRKACA-mediated long-term memory
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text
  • formation and maintenance of PSD
  • synaptic
  • protein sorting machining
  • PATHWAY
    metabolism
    signaling neurotransmission
    synaptic communication and plasticity
    a component
  • SIK2-CDK5R1-PJA2 complex is essential for glucose homeostasis and provides a link between CDK5R1-CDK5 and the AMPK family in excitable cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SPTBN1 in a TGF-beta-dependent manner, with a fivefold increase of PJA1 and PJA2 expression and a subsequent decrease in SPTBN1 and SMAD4 expression, in gastrointestinal cancer cell lines
  • forms a stable complex with, and is phosphorylated by, PRKACA
  • cell & other
    REGULATION
    Phosphorylated by PRKACA
    Other downregulated by exonotomy
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS