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FLASH GENE
Symbol PJA1 contributors: mct - updated : 18-01-2016
HGNC name praja ring finger 1
HGNC id 16648
Location Xq13.1      Physical location : 68.380.581 - 68.385.365
Synonym name
  • RING finger protein 70
  • E3 ubiquitin-protein ligase Praja1
  • Synonym symbol(s) FLJ11830, RNF70, Praja-1, PRAJA1
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 4.78 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2880 71 643 - 2002 12036302
    2 - 2554 - 588 - 2002 12036302
    3 - 2316 - 455 - 2002 12036302
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Nervousbrainforebraincerebral lobeparietal  Homo sapiens
     brainhindbraincerebellum highly Homo sapiens
     brainbasal nucleiputamen highly Homo sapiens
     brainhindbrainmedulla oblongata highly Homo sapiens
     brainforebraincerebral lobefrontalhighly Homo sapiens
     brainforebraincerebral lobeoccipitalhighly Homo sapiens
     brainforebraincerebral cortex highly Homo sapiens
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one cysteine-rich domain
  • a ring finger binding domain
  • a bipartite nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to murine Pja1
    intraspecies homolog to PJA2
    Homologene
    FAMILY
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in protein ubiquination in the brain (functioning as E3 ubiquitin ligase)
  • transcription repressor activity
  • RING-H2 protein, manifesting substantial E3-dependent ubiquitination of SPTBN1 and SMAD3, but not SMAD4
  • E3 implicated in bone development and highly expressed in brain
  • potential role for PRAJA1 in regulating the level of PRC2 (polycomb repressive complex 2) by targeting its free subunits for Ub-mediated proteasomal degradation
  • may act as a potential agent for the prevention and treatment of infectious and inflammatory diseases
  • PJA1 plays an important role in the restriction of DNA viruses and extrachromosomal DNAs coordinating with the SMC5/6 complex
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBCH5
  • promoting downregulation and ubiquitination of DLX5 by controlling the stability of MAGED1 (Dixin 1) through its ubiquitin ligase activity
  • interacting with SPTBN1 in a TGF-beta-dependent manner, with a fivefold increase of PJA1 and PJA2 expression and a subsequent decrease in SPTBN1 and SMAD4 expression, in gastrointestinal cancer cell lines
  • can target PRC2 (polycomb repressive complex 2) subunits for proteasomal degradation
  • MAGED1 regulates DLX-dependent migration-related transcription by binding to NDN or PJA1
  • PJA1, through ubiquitination and degradation of MAGED1, inhibits neuronal differentiation
  • PJA1 interacts with the SMC5/6 complex in the nucleus and facilitates the binding of NSMCEA4 to viral and episomal DNAs
  • PJA1 attenuates the interaction of NSMCE4A with NSMCE1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS