protein
| UBCH5 |
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promoting downregulation and ubiquitination of DLX5 by controlling the stability of MAGED1 (Dixin 1) through its ubiquitin ligase activity |
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interacting with SPTBN1 in a TGF-beta-dependent manner, with a fivefold increase of PJA1 and PJA2 expression and a subsequent decrease in SPTBN1 and SMAD4 expression, in gastrointestinal cancer cell lines |
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can target PRC2 (polycomb repressive complex 2) subunits for proteasomal degradation |
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MAGED1 regulates DLX-dependent migration-related transcription by binding to NDN or PJA1 |
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PJA1, through ubiquitination and degradation of MAGED1, inhibits neuronal differentiation |
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PJA1 interacts with the SMC5/6 complex in the nucleus and facilitates the binding of NSMCEA4 to viral and episomal DNAs |
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PJA1 attenuates the interaction of NSMCE4A with NSMCE1 |