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FLASH GENE
Symbol PIWIL3 contributors: mct - updated : 22-06-2009
HGNC name piwi-like 3 (Drosophila)
HGNC id 18443
Location 22q11.23      Physical location : 25.115.000 - 25.170.683
Synonym name piwi-like 3
Synonym symbol(s) HIWI3
DNA
TYPE functioning gene
STRUCTURE 55.68 kb     21 Exon(s)
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3504 101 882 - 2003 12906857
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multiple arginine-glycine (RG) and arginine-alanine (RA) repeats at the N-terminus, and methylation of these arginine sites is important for recruiting the Tudor domain-containing (TDRD) group of germ-line-enriched Tudor domain proteins
  • PAZ motif in the middle
  • Piwi motif in the C-terminal region
  • HOMOLOGY
    Homologene
    FAMILY
  • argonaute family
  • PIWI subfamily
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nuclear import of Ago proteins in cells influenced by IPO8
    basic FUNCTION
  • may be involved in the development and maintenance of stem cells through the RNA-mediated gene-quelling mechanisms associated with DICER1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DICER1
  • cell & other
  • cellular binding partners of miRNAs as well as other small RNAs and are therefore key components of miRNP
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS