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FLASH GENE
Symbol PIWIL2 contributors: mct - updated : 13-09-2020
HGNC name piwi-like 2 (Drosophila)
HGNC id 17644
Location 8p21.3      Physical location : 22.132.809 - 22.213.584
Synonym name
  • Miwi like
  • Hiwi-like
  • cancer/testis antigen 80
  • Synonym symbol(s) MILI, PIWIL1L, FLJ10351, Hiwi-like, HILI, CT80, MGC133049
    EC.number 3.1.26.-
    DNA
    TYPE functioning gene
    STRUCTURE 80.78 kb     23 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    text structure
  • PIWIL2 alternative promoter in exon 7 functions as an enhancer for gene PHYHIP located 60Kb upstream
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 3997 110 973 - 2004 14736746
    23 - 3636 110 973 - 2004 14736746
    22 - 5006 - 937 - 2004 14736746
    - - - 60 - widely expressed in various types of tumors, and in testicular cancer cell lines expression is significantly higher in undifferentiated seminomas and appears to be substantially decreased in mixed and nonseminomatous testicular germ cell tumor (TGCT) 2017 28545024
  • intragenic promoter responsible for the activation of PL2L60, is located in the intron 10 of the host gene PIWIL2
  • - - - 80 - in testicular cancer cell lines -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte Homo sapiens
    Reproductivespermatogonia Homo sapiens
    cell lineage
    cell lines testicular germ cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple arginine-glycine (RG) and arginine-alanine (RA) repeats at the N-terminus, and methylation of these arginine sites is important for recruiting the Tudor domain-containing (TDRD) group of germ-line-enriched Tudor domain proteins
  • conserved PAZ and Piwi domains
  • HOMOLOGY
    Homologene
    FAMILY
  • argonaute family
  • PIWI subfamily
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • nuclear import of Ago proteins in cells influenced by IPO8
  • co-localizes with ASZ1 in intermitochondrial cement
  • basic FUNCTION
  • involved in dorso-ventral axis formation
  • playing important roles in stem-cell self-renewal, RNA silencing and translational regulation
  • essential role for the differentiation of spermatocytes
  • essential for the self-renewing division and differentiation of germ line stem cells but does not affect initial establishment of the germ line stem cell population at 7 days postpartum
  • may positively regulate translation and that such regulation is required for germ line stem cell self-renewal
  • PIWIL2 is required for the repair of DNA-damage induced by various types of genotoxic agents
  • role for PIWIL2 in DNA repair, suggesting that PIWIL2 may act as a gatekeeper against DNA damage-mediated tumorigenesis
  • significant association between the expression of PIWIL2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients
  • PIWIL2 modulates the proliferation and metastasis of colon cancer via regulation of MMP9 transcriptional activity
  • function of PIWIL2 in melanoma metastasis and tumor progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • forms a stable RNA-independent complex with EIF3A and associates with the EIF4E- and EIF4G1
  • direct physical interaction of PIWIL1 and PIWIL2 with TDRD6
  • interacts with TDRD1 in the nuage and chromatoid body
  • formation of complexes between PIWIL1, PIWIL2 and TDRD1 is critical for the integrated subcellular localizations of these proteins, and is presumably essential for spermatogenesis
  • interacting with MOV10L1 (interacts also with heat shock 70-kDa protein 2 (HSPA2), a testis-enriched chaperone expressed in pachytene spermatocytes, and essential for male fertility
  • direct interaction between PIWIL2 and TDRD12 (
  • PIWIL2 suppressed GSK3B induced phosphorylation and ubiquitination of CTNNB1, and thus increased CTNNB1 accumulation in the nucleus
  • TEX15 is associated with PIWIL2 in testis
  • cell & other
  • cellular binding partners of miRNAs as well as other small RNAs and are therefore key components of miRNP
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in testicular germ cell tumors
    tumoral     --over  
    in glioma tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PIWIL2 expression may be considered a potential prognostic biomarker for resectable pancreatic cancer and may serve to guide subsequent adjuvant treatment decisions
  • PIWIL1, PIWIL2, and PIWIL4 are potential prognostic biomarkers in patients with renal cell carcinoma
  • may be used as a potential diagnostic marker of glioma
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be used as a therapeutic target of glioma
    ANIMAL & CELL MODELS