basic FUNCTION
| involved in dorso-ventral axis formation |
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playing important roles in stem-cell self-renewal, RNA silencing and translational regulation |
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essential role for the differentiation of spermatocytes |
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essential for the self-renewing division and differentiation of germ line stem cells but does not affect initial establishment of the germ line stem cell population at 7 days postpartum |
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may positively regulate translation and that such regulation is required for germ line stem cell self-renewal |
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PIWIL2 is required for the repair of DNA-damage induced by various types of genotoxic agents |
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role for PIWIL2 in DNA repair, suggesting that PIWIL2 may act as a gatekeeper against DNA damage-mediated tumorigenesis |
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significant association between the expression of PIWIL2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients |
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PIWIL2 modulates the proliferation and metastasis of colon cancer via regulation of MMP9 transcriptional activity |
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function of PIWIL2 in melanoma metastasis and tumor progression |