SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
text
| in the Golgi apparatus in interphase cells, but it is recruited to the cleavage furrow and the midbody during cytokinesis |
|
is an essential protein and is required for anterograde transport from the trans-Golgi network to the plasma membrane |
|
translocates from the Golgi complex to the plasma membrane in response to Growth factor stimulation |
basic FUNCTION
| playing an essential role for cytokinesis |
|
preemptive role for the PITPNM1 homologs in excluding endogenous and exogenous modified purine dNTPs from incorporation into DNA |
|
participate in many cellular processes including cell signaling, membrane traffic, and lipid metabolism |
|
PITPNM1, PITPNM2, PITPNM3, PITPNA, PITPNB, PITPNC1 are regulators of phosphoinositide pathways by recruitment to membranes through specific protein interactions to promote molecular exchange between closely opposed membranes i.e., at membrane contact sites |
|
lipid-transfer protein PITPNM1 enhances EMT in mammary epithelial and breast cancer cells, and facilitates breast cancer metastasis |
|
PITPNM1, PITPNM2, work in tandem to achieve different levels of feedback based on the consumption of PM (plasma membrane) Phosphatidylinositol 4,5-Bisphosphate and function at ER-PM junctions to mediate nonvesicular lipid transport between the ER and the PM |