basic FUNCTION
| transfers phosphatidylinositol from one mebrane compartment to one another |
|
likely implicated in the maintenance of diacylglycerol (DAG) levels and secretory function at Golgi membranes (pMID: 17543578) |
|
executes likely its function following recruitment to membranes via its PITP domain and the C-terminal end of the protein could regulate entry to the hydrophobic cavity |
|
participate in many cellular processes including cell signaling, membrane traffic, and lipid metabolism |
|
when containing phosphatidic acid (PA), regulates an effector protein or can facilitate lipid transfer between membrane compartments |
|
PITPNM1, PITPNM2, PITPNM3, PITPNA, PITPNB, PITPNC1 are regulators of phosphoinositide pathways by recruitment to membranes through specific protein interactions to promote molecular exchange between closely opposed membranes i.e., at membrane contact sites |
|
is a PI4P-binding protein that enhances vesicular secretion capacity in malignancy |