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FLASH GENE
Symbol PIRT contributors: mct/npt - updated : 21-06-2016
HGNC name phosphoinositide interacting regulator of transient receptor potential channels
HGNC id 37239
Location 17p12      Physical location : 10.725.792 - 10.741.418
Genatlas name phosphoinositide interacting protein
Synonym name hypothetical protein LOC644139
Synonym symbol(s) hCG_1776018, LOC644139
DNA
TYPE functioning gene
STRUCTURE 15.63 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3466 - 137 - 2008 18455988
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 gangliasensory gangliadorsal root  
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous  specific Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminus containing a cluster of positively charged residues, a characteristic of PIP-binding domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text expression in nociceptive neurons
    basic FUNCTION
  • functioning as a regulatory subunit of the TRPV1 complex
  • plays an essential role only in the activating effect of PIP2 but not in its inhibitory effect
  • may regulate the activities of other TRP channels via PIP2 and play critical roles in nociception
  • not required for INPP5J regulation of TRPV1
  • play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation
  • its function extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways
  • is an endogenous regulator of TRPM8
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • positively regulates TRPV1 activity, raising the possibility that TRPV1 and PIRT may form a complex
  • binds both phosphatidylinositol-4,5-bisphosphate (PIP2) and TRPV1 and positively regulates TRPV1 via INPP5J
  • binds phosphoinositides and may act as the INPP5J sensor for TRPV1
  • PIRT and TRPV1 will lie in close proximity and may even form a protein complex
  • increase the sensitivity of TRPV1 channel and modulate its role in heat pain
  • PIRT regulates the function of TRPM8 and its role in detecting cold
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Pirt-/- mice were deficient in inflammatory hyperalgesia, similar to TRPV1 knock-out mice
  • Pirt(-/-) mice exhibit decreased behavioural responses to cold and cool temperatures