basic FUNCTION
| functioning as a regulatory subunit of the TRPV1 complex |
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plays an essential role only in the activating effect of PIP2 but not in its inhibitory effect |
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may regulate the activities of other TRP channels via PIP2 and play critical roles in nociception |
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not required for INPP5J regulation of TRPV1 |
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play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation |
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its function extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways |
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is an endogenous regulator of TRPM8 |