Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PIP5K1B contributors: mct/npt - updated : 10/10/2008
HGNC name phosphatidylinositol-4-phosphate 5-kinase, type I, beta
HGNC id 8995
Location 9q13      Physical location : 71.320.615 - 71.624.090
Synonym name
  • protein STM-7
  • PtdIns(4)P-5-kinase beta
  • Synonym symbol(s) MSS4, STM7
    EC.number 2.7.1.37, 2.7.1.68
    DNA
    TYPE functioning gene
    STRUCTURE 303.48 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure with an open reading frame of 1620bp, extending upon 220kb
    MAPPING cloned Y linked N status confirmed
    regionally located extending distally in the Friedreich critical region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2654 60.9 540 - Ewing (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
    Hearing/Equilibriumear   highly
    Reproductivemale systemtestis  highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C terminus interacted with EBP50
  • HOMOLOGY
    interspecies homolog to yeast MSS4,strongly
    homolog to murine Pip5k1a
    Homologene
    FAMILY
  • ptdins(4)p-5-kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • 1-phosphatidylinositol-4-phosphate 5-kinase activity
  • having a role in organizing signaling at the cell rear
  • controls neutrophil polarity and directional movement
  • PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    putative
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS