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FLASH GENE
Symbol PIP5K1A contributors: mct/npt - updated : 16-04-2014
HGNC name phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
HGNC id 8994
Location 1q21.3      Physical location : 151.171.020 - 151.222.006
Synonym name
  • 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
  • PtdIns(4)P-5-kinase alpha
  • Synonym symbol(s) PIP5KIalpha, PIPK alpha
    EC.number 2.7.1.37, 2.7.1.68
    DNA
    TYPE functioning gene
    STRUCTURE 51.50 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D1S498 - PIP5K1A - S100A10 - LOR - D1S2347 - D1S2858 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3824 62.5 562 - 2008 1853498
    15 - 3785 61 549 - 2008 1853498
    14 - 3704 57.9 522 - 2008 1853498
    14 - 3638 55.9 500 - 2008 1853498
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text plasma membrane-associated protein
    basic FUNCTION
  • phosphatidylinositol-4-phosphate-5 kinase, type 1 alpha, putatively involved in membrane ruffle formation
  • playing a role in regulating stress-induced apoptosis
  • activation of KIF2A is not sufficient but is essential for the function of PIP5K1A
  • PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis
  • cytosolic PIP5K1A has been implicated in several cellular events like endocytosis, membrane ruffling and migration; the nuclear pool has been shown to be involved in pre-mRNA splicing events
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIPSL is the fusion of phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) and 26S proteasome subunit (S5a/PSMD4) genes
  • suppressed the elongation of axon branches in a KIF2A-dependent manner, suggesting a unique PIPK-mediated mechanism controlling MT dynamics in neuronal development
  • cell & other
    REGULATION
    activated by the small G protein ADP-ribosylation factor ARF6
    Other nuclear PIP5K1A is modified by SUMO1 in normal cells
    modified by polySUMO-2 only during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene potentialy target for the treatment of prostate cancer
    Marker
    Therapy target
    ANIMAL & CELL MODELS