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FLASH GENE
Symbol PIP5K1A contributors: mct/npt - updated : 16-04-2014
HGNC name phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
HGNC id 8994
Location 1q21.3      Physical location : 151.171.020 - 151.222.006
Synonym name
  • 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
  • PtdIns(4)P-5-kinase alpha
  • Synonym symbol(s) PIP5KIalpha, PIPK alpha
    EC.number 2.7.1.37, 2.7.1.68
    DNA
    TYPE functioning gene
    STRUCTURE 51.50 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D1S498 - PIP5K1A - S100A10 - LOR - D1S2347 - D1S2858 - cen
    Authors Gene Map (98)
    Physical map
    ENSA 1q21.2 endosulfine alpha GPP34R 1q21.3 GPP34-related protein DKFZP434A1315 1q21.3 hypothetical protein DKFZp434A1315 CTSS 1q21 cathepsin S CTSK 1q21 cathepsin K (pycnodysostosis) ARNT 1q21 aryl hydrocarbon receptor nuclear translocator HCP1 1q21.3 cytochrome c, somatic pseudogene SETDB1 1q21 SET domain, bifurcated 1 LASS2 1q11 LAG1 longevity assurance homolog 2 (S. cerevisiae) ANXA9 1q21 annexin A9 FLJ11280 1q21.3 hypothetical protein FLJ11280 BNIPL 1q21.2 BCL2/adenovirus E1B 19kD interacting protein like HTCD37 1q21 TcD37 homolog FLJ20519 1q21.3 hypothetical protein FLJ20519 SPEC1 1q21.2 hypothetical protein FLJ20519 AF1Q 1q21 hypothetical protein FLJ20519 MGC29891 1q21.3 hypothetical protein MGC29891 SEMA6C 1q21.2 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C FLJ23467 1q21.3 hypothetical protein FLJ23467 LOC388695 1 similar to hypothetical protein SB145 SCNM1 1q21.3 sodium channel modifier 1 TMOD4 1q12 tropomodulin 4 (muscle) TCFL1 1q21 transcription factor-like 1 PIP5K1A 1q22-q24 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha PSMD4 1q21.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 KIAA1441 1q21.3 KIAA1441 protein PIK4CB 1q21 phosphatidylinositol 4-kinase, catalytic, beta polypeptide RFX5 1q21 regulatory factor X, 5 (influences HLA class II expression) SELENBP1 1q21-q22 selenium binding protein 1 PSMB4 1q21 proteasome (prosome, macropain) subunit, beta type, 4 POGZ 1q21.1 pogo transposable element with ZNF domain CGN 1q21 cingulin TUFT1 1q21-q23 tuftelin 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3824 62.5 562 - 2008 1853498
    15 - 3785 61 549 - 2008 1853498
    14 - 3704 57.9 522 - 2008 1853498
    14 - 3638 55.9 500 - 2008 1853498
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland highly
     male systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text plasma membrane-associated protein
    basic FUNCTION
  • phosphatidylinositol-4-phosphate-5 kinase, type 1 alpha, putatively involved in membrane ruffle formation
  • playing a role in regulating stress-induced apoptosis
  • activation of KIF2A is not sufficient but is essential for the function of PIP5K1A
  • PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis
  • cytosolic PIP5K1A has been implicated in several cellular events like endocytosis, membrane ruffling and migration; the nuclear pool has been shown to be involved in pre-mRNA splicing events
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIPSL is the fusion of phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) and 26S proteasome subunit (S5a/PSMD4) genes
  • suppressed the elongation of axon branches in a KIF2A-dependent manner, suggesting a unique PIPK-mediated mechanism controlling MT dynamics in neuronal development
  • cell & other
    REGULATION
    activated by the small G protein ADP-ribosylation factor ARF6
    Other nuclear PIP5K1A is modified by SUMO1 in normal cells
    modified by polySUMO-2 only during apoptosis
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene potentialy target for the treatment of prostate cancer
    Marker
    Therapy target
    ANIMAL & CELL MODELS