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FLASH GENE
Symbol PIP4K2A contributors: npt - updated : 14-11-2005
HGNC name phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
HGNC id 8997
Location 10p12.2-p11.23      Physical location : 22.823.766 - 23.003.503
Synonym name
  • diphosphoinositide kinase
  • 1-phosphatidylinositol-4-phosphate kinase
  • PtdIns(5)P-4-kinase isoform 2-alpha
  • type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform
  • Synonym symbol(s) PIPK, PIP5KII-alpha, PIP5K2A, FLJ13267, PIP5K2, PtdIns
    EC.number 2.7.1.68, 2.7.1.149
    DNA
    TYPE functioning gene
    STRUCTURE 179.00 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3833 46 406 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one PI5K domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Pip5k2a
    Homologene
    FAMILY
  • phosphatidylinositol-4-phosphate 5-kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be involved in the regulation of secretion, cell proliferation, differentiation, and motility
  • enzyme capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS