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FLASH GENE

Symbol

PIP

contributors: mct - updated : 08-02-2018

HGNC name	prolactin-induced protein
HGNC id	8993

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q34      Physical location : 142.829.173 - 142.836.834
Synonym name	gross cystic disease fluid protein 15
	secretory actin-binding protein
Synonym symbol(s)	GP17, GcDFP15, GCDFP-15, GPIP4, SABP

DNA

TYPE	functioning gene
STRUCTURE	10.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002652 4 - 591 NP_002643 17 146 - 2012 2220993

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth           salivary gland         Reproductive male system seminal vesicles       Skin/Tegument skin appendages skin gland sweat gland apocrine sweat gland   Visual eye lacrimal gland

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage
cell lines	breast cancer cell line T-47D
fluid/secretion	sweat, salivar, tears, milk, and seminal fluid

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

secretory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,nucleus

basic FUNCTION	inhibition T lymphocyte apoptosis
	having ability to bind a large array of proteins indicates its multifaceted role in various biological processes, such as fertility, immunoregulation, antimicrobial activity, apoptosis, and tumor progression
	aspartyl protease unessential for normal mammalian cell function, that is required for the proliferation and invasion of some breast cancer (BCa) cell types
	breast cancer-related protein that is expressed in a majority of breast tumors and has a significant function in the biology of this disease
	has key cellular functions in breast cancer that include promoting invasion and cell cycle progression
	PIP expression likely regulates the process of cell adhesion in breast cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

as ALB has been known to preserve the motility of sperm, native ALB-PIP complex formation may point towards an important role of PIP, which can directly be correlated with male fertility/infertility

INTERACTION

DNA

RNA

small molecule

protein	CD4
	RUNX2, a pro-metastatic transcription factor, functionally interacts with the Androgen Receptor (AR) to regulate PIP expression
	interaction between PIP and SEMG1 fragments in seminal plasma or elsewhere with a suggestive role in reproductive physiology which might be helpful for spermatozoa to acquire their motility

cell & other

REGULATION

induced by

lactogenic hormones

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   decreased in tape-stripped stratum corneum (SC) samples from atopic dermatitis (AD) patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PIP in stratum corneum (SC) is a potential marker for dysregulated sweating in atopic dermatitis (AD)
	diagnostic biomarker for the histopathological diagnosis of breast cancer
	best independent biomarker able to discriminate between Keratoconus (KC) and controls
Therapy target
	System Type Disorder Pubmed cancer reproductive breast pharmacological inhibition of PIP may therefore serve the bases for both augmentation of existing therapies for hormone-dependent tumors and the development of novel therapeutic approaches for hormone-resistant BCa

ANIMAL & CELL MODELS