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FLASH GENE
Symbol PIP contributors: mct - updated : 08-02-2018
HGNC name prolactin-induced protein
HGNC id 8993
Location 7q34      Physical location : 142.829.173 - 142.836.834
Synonym name
  • gross cystic disease fluid protein 15
  • secretory actin-binding protein
  • Synonym symbol(s) GP17, GcDFP15, GCDFP-15, GPIP4, SABP
    DNA
    TYPE functioning gene
    STRUCTURE 10.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    Physical map
    EPHB6 7q33-q35 EphB6 TRPV6 7q33-q34 transient receptor potential cation channel, subfamily V, member 6 TRPV5 7q35 transient receptor potential cation channel, subfamily V, member 5 C7orf34 7q35 chromosome 7 open reading frame 34 KEL 7q33 Kell blood group LOC135924 7q35 similar to Olfactory receptor 9A2 LOC346517 7q35 similar to Olfactory receptor 6V1 sdolf 7q35 olfactory receptor sdolf PIP 7q34 prolactin-induced protein TAS2R39 7q35 taste receptor, type 2, member 39 TAS2R40 7q35 taste receptor, type 2, member 40 LOC51064 7q35 glutathione S-transferase subunit 13 homolog FLJ90586 7q35 hypothetical protein FLJ90586 CASP2 7q34-q35 caspase 2, apoptosis-related cysteine protease (neural precursor cell expressed, developmentally down-regulated 2) LOC346521 7q35 similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) CLCN1 7q35 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) KIAA0773 7q35 chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) LOC202775 7q35 hypothetical LOC202775 ZYX 7q34-q35 zyxin EPHA1 7q32-q34 EphA1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 591 17 146 - 2012 2220993
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
     salivary gland    
    Reproductivemale systemseminal vesicles   
    Skin/Tegumentskin appendagesskin glandsweat glandapocrine sweat gland 
    Visualeyelacrimal gland   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines breast cancer cell line T-47D
    fluid/secretion sweat, salivar, tears, milk, and seminal fluid
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibition T lymphocyte apoptosis
  • having ability to bind a large array of proteins indicates its multifaceted role in various biological processes, such as fertility, immunoregulation, antimicrobial activity, apoptosis, and tumor progression
  • aspartyl protease unessential for normal mammalian cell function, that is required for the proliferation and invasion of some breast cancer (BCa) cell types
  • breast cancer-related protein that is expressed in a majority of breast tumors and has a significant function in the biology of this disease
  • has key cellular functions in breast cancer that include promoting invasion and cell cycle progression
  • PIP expression likely regulates the process of cell adhesion in breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • as ALB has been known to preserve the motility of sperm, native ALB-PIP complex formation may point towards an important role of PIP, which can directly be correlated with male fertility/infertility
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD4
  • RUNX2, a pro-metastatic transcription factor, functionally interacts with the Androgen Receptor (AR) to regulate PIP expression
  • interaction between PIP and SEMG1 fragments in seminal plasma or elsewhere with a suggestive role in reproductive physiology which might be helpful for spermatozoa to acquire their motility
  • cell & other
    REGULATION
    induced by lactogenic hormones
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased in tape-stripped stratum corneum (SC) samples from atopic dermatitis (AD) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PIP in stratum corneum (SC) is a potential marker for dysregulated sweating in atopic dermatitis (AD)
  • diagnostic biomarker for the histopathological diagnosis of breast cancer
  • best independent biomarker able to discriminate between Keratoconus (KC) and controls
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    pharmacological inhibition of PIP may therefore serve the bases for both augmentation of existing therapies for hormone-dependent tumors and the development of novel therapeutic approaches for hormone-resistant BCa
    ANIMAL & CELL MODELS