SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,interspace
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus
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| precursor form of PINK1 translocates to the mitochondria and is processed into two cleaved forms of PINK1, which in turn localize more to the cytosolic than mitochondrial fraction |
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cytosolic and mitochondrially localized |
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with BECN1, localize to the mitochondrial compartment |
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localize to mitochondria, and upon entry into the organelle, is cleaved to produce a 53 kDa protein (deltaN-PINK1) |
basic FUNCTION
| acts with Parkin in a common pathway in maintaining mitochondrial integrity and function in both muscles and dopaminergic neurons |
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plays an essential role in maintaining neuronal survival by preventing neurons from undergoing oxidative stress |
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a possible regulatory role for the PINK1/Parkin pathway in mitochondrial fission |
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important for mitochondrial function and provides critical protection against both intrinsic and environmental stress |
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regulates calcium efflux from the mitochondria via the mitochondrial Na(+)/Ca(2+) exchanger |
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functional links between PINK1, Parkin and the selective autophagy of mitochondria |
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with PARK2 are intimately involved in preventing mitochondrial dysfunction |
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promotes proteasomal degradation of PARK2 |
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PINK1 and HSPA9 accumulated in different cellular compartments, and these two proteins share, at least partially, the same pathway of mitochondrial import |
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PINK1 and HSPA9 are synthesized as a precursor protein which is cleaved into its mature form after import into mitochondria in a mitochondrial membrane potential-dependent manner |
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required for the recruitment of parkin to depolarize mitochondria prior to selective clearance of the functionally inactive organelles by autophagy |
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PINK1 and PARK2 are thus required for the removal of damaged mitochondria in dopaminergic cells, and inhibition of this pathway may lead to the accumulation of defective mitochondria which may contribute to Parkinson disease pathogenesis |
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restoration of autophagy in PINK1-silenced cells by PARK2 reverses ATP synthesis inhibition and the ubiquitination of MFN1 and MFN2 play a role in PINK1/PARK2-mediated mitophagy |
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PARK7 works in parallel to the PINK1/parkin pathway to maintain mitochondrial function in the presence of an oxidative environment |
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differential localization to the inner and outer mitochondrial membranes appears to regulate PINK1 stability and function |
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exerts its cytoprotective function not only in mitochondria but also in the cytoplasm through activation of CRTC2 |
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key role for PINK1 in the regulation of mitochondrial homeostasis and energy metabolism under physiological conditions |
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PINK1 activity is crucial for postnatal myocardial development, through its role in maintaining mitochondrial function, and redox homeostasis in cardiomyocytes |
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crucial in the maintenance of mitochondrial function and redox homeostasis in cardiomyocytes |
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regulates histone methylation and gene expression through the polycomb repressor complex |
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importance of PINK1 as a mitochondrial protein functioning to regulate the complex interplay between mitochondrial function, ROS production, and hypertrophic signaling in the heart |
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because PINK1 acts via PARK2 in arresting mitochondria, PINK1 was predicted to require PARK2 to promote RHOT1, RHOT2 degradation |
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PRKN and PINK1 are regulated by neddylation and impaired NEDD8 modification of these proteins likely contributes to Parkinson disease pathogenesis |
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PINK1 is imported into mitochondria by a unique pathway that is independent of the TOM core complex but crucially depends on the import receptor TOMM70A |
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protects cells from oxidative stress by suppressing mitochondrial cytochrome c release, thereby preventing cell death |
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accumulates on depolarized mitochondria, where it recruits PARK2 to mainly induce K63-linked chain ubiquitination of outer membrane proteins and eventually mitophagy |
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its function is related to mitochondria homeostasis ( |
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could regulate the subcellular localization, phosphorylation, and stability of EED/WAIT1 |
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acts as an upstream factor for PARK2 and is essential both for the activation of latent E3 PARK2 activity and for recruiting PARK2 onto depolarized mitochondria |
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PINK1 and PARK2, mediate local mitophagy of dysfunctional mitochondria in neuronal axons |
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is pivotal to maintain mitochondrial homeostasis in neural cells |
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