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FLASH GENE
Symbol PIM3 contributors: mct - updated : 06-03-2013
HGNC name pim-3 oncogene
HGNC id 19310
Location 22q13.33      Physical location : 50.354.142 - 50.357.719
Synonym name serine/threonine-protein kinase Pim-3
Synonym symbol(s) pim-3
EC.number 2.7.11.1,
DNA
TYPE functioning gene
STRUCTURE 3.00 kb     6 Exon(s)
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunespleen    
Nervousbrain    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
  • hepatocellular carcinoma cell lines
  • pancreas cancer cell lines
  • Ewing's family tumor cell lines
  • fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one protein kinase domain
    HOMOLOGY
    interspecies ortholog to murine Pim
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • PIM family, related to camodulin-calcium family of protein-kinases
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • promoting cell prolifeeration and preventing cell death
  • can inactivate BAD by phosphorylating its Ser(112) in colon cancer cells and thus may prevent apoptosis and promote progression of colon cancer
  • promote cell cycle progression and tumorigenesis by down-regulating CDKN1B expression at both transcriptional and posttranslational levels
  • PIM1, PIM2, PIM3 have been implicated in the regulation of apoptosis, metabolism, cell cycle, and homing and migration, which has led to the postulation of these proteins as interesting targets for anticancer drug discovery
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • promoting the phosphorylation of BAD and inhibiting its pro-apoptotic function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in several human cancers
    tumoral     --other  
    aberrantly expressed in malignant lesions of endoderm-derived organs, liver and pancreas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    compound Pim knockhout mice show a profound reduction of body size and non efficient proliferation of peripheral T lymphocytes