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FLASH GENE
Symbol PILRA contributors: mct/pgu - updated : 13-04-2010
HGNC name paired immunoglobin-like type 2 receptor alpha
HGNC id 20396
Location 7q22.1      Physical location : 99.971.067 - 99.997.722
Synonym name
  • cell surface receptor FDF03
  • inhibitory receptor PILRalpha
  • paired immunoglobin-like receptor alpha
    • Synonym symbol(s) FDF03, PILR(ALPHA)
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text mapped 5.6 kb downstream from PILRB, in a head to tail orientation
    STRUCTURE 26.66 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1323 33.9 303 - 2000 10660620
  • isoform 1
  • precursor
    • 6 splicing 1104 - 230 - 2000 10903717
  • isoform 2
  • secreted isoform
    • 5 - 1070 - 175 - 2000 10903717
  • isoform 3, precursor
  • secreted isoform
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    Reproductivefemale systemplacenta   
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte Homo sapiens
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an Ig-like cysteine-based motif involved in intradomain disulfide bonding
  • a potential N-glycosylation site,numerous O-glycosylation sites
  • a transmembrane domain and 3 potential tyrosine phosphorylation sites, 2 of which are within an immunoreceptor tyrosine-based inhibitory motif (ITIM)
    • conjugated GlycoP , PhosphoP
    mono polymer monomer
    HOMOLOGY
    intraspecies homolog to PILR(BETA)
    Homologene
    FAMILY
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6 and PTPN11 that block signal transduction through dephosphorylation of signaling molecules
  • coreceptor for HSV-1 infection
  • importance of PILRA and PILRB in innate immunity and the control of inflammation
  • PANP and PILRA interactions might be involved in neural immune disorders such as multiple sclerosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTPN6, PTPN11
  • associating with glycoprotein B of HSV-1
  • CD99 was recognized by both PILRA and PILRB , but PILRA can bind to CD99 with low affinity
  • binds and activates immune inhibitory receptor PILRA in trans, a process that requires sialidation of PIANP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS