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FLASH GENE
Symbol PIK3R6 contributors: mct - updated : 10-02-2014
HGNC name phosphoinositide-3-kinase, regulatory subunit 6
HGNC id 27101
Location 17p13.1      Physical location : 8.706.054 - 8.770.994
Synonym name
  • p84 PI3K adapter protein
  • PI3Kgamma adapter protein of 87 kDa
  • p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
  • Synonym symbol(s) p84, C17orf38, HsT41028, p87PIKAP, p84 PIKAP, p87(PIKAP)
    DNA
    TYPE functioning gene
    STRUCTURE 64.94 kb     20 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text 1
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3061 84 754 - 2005 15797027
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to PIK3R5
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • differential functions of the two PIK3CG regulatory subunits PIK3R5, and PIK3R6 in the process of oncogenesis
  • non-catalytic subunit assumed to be redundant adaptors for GNB1/GNGT1 enabling G-protein-coupled receptor-mediated regulation of PIK3CG
  • specific regulatory roles of PIK3R5, PIK3R6 in the differentiation of PIK3CG a signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PIK3CG has two potential regulatory subunits PIK3R5, PIK3R6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of PIK3R6 to PIK3CG substantially increases the ability of Gbetagamma to stimulate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) production
  • like PIK3R5, PIK3R6 binds to both PIK3CG and Gbetagamma and mediates activation of PIK3CG downstream of G protein-coupled receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS