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FLASH GENE
Symbol PIK3CB contributors: mct/npt/pgu - updated : 19-04-2010
HGNC name phosphoinositide-3-kinase, catalytic, beta polypeptide
HGNC id 8976
Location 3q22.3      Physical location : 138.374.232 - 138.478.185
Synonym name
  • PtdIns-3-kinase p110
  • PI3-kinase p110 subunit beta
  • catalytic phosphatidylinositol 3-kinase beta
  • Synonym symbol(s) PIK3C1, PI3K, PI3Kbeta, p110-BETA, DKFZp779K1237, MGC133043, PI3KCB, PIK3C1
    EC.number 2.7.1.153
    DNA
    TYPE functioning gene
    STRUCTURE 103.96 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC3295 3q22.3 hypothetical protein MGC3295 NCK1 3q21 NCK adaptor protein 1 MGC34923 3q22.3 hypothetical protein MGC34923 NPM1P17 3q22.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 17 SOX14 3q23 SRY (sex determining region Y)-box 14 LOC344829 3q22.3 similar to Heat shock cognate 71 kDa protein CLDN18 3q22.3 claudin 18 FLJ32844 3q22.3 hypothetical protein FLJ32844 alpha4GnT 3p14.3 hypothetical protein FLJ32844 DBR1 3q22.3 debranching enzyme homolog 1 (S. cerevisiae) HSPC056 3q22.3 HSPC056 protein TXL-2 3q22.3 thioredoxin-like 2 MRAS 3q22.3 muscle RAS oncogene homolog CHR3SYT 3q22.3 chr3 synaptotagmin BITE 3q22-q23 p10-binding protein FAIM 3q23 Fas apoptotic inhibitory molecule LOC256374 3q22.3 similar to peptidylprolyl isomerase A PIK3CB 3q22-q23 phosphoinositide-3-kinase, catalytic, beta polypeptide LOC391582 3 similar to ATP synthase lipid-binding protein, mitochondrial precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2 LOC389151 3 hypothetical gene supported by AK127998 LOC389152 3 hypothetical gene supported by AK128089 BPESC1 3q23 blepharophimosis, epicanthus inversus and ptosis, candidate 1 MRPS22 3q23 mitochondrial ribosomal protein S22 COPB2 3q23 coatomer protein complex, subunit beta 2 (beta prime) RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3213 - 1070 - 1993 8246984
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   moderately
    Digestiveintestinesmall intestine  moderately
     intestinelarge intestinecolon moderately
     mouthtongue  highly
    Endocrinethyroid    
    Nervousbrain   moderately
    Reproductivefemale systembreastmammary gland moderately
     female systemuteruscervix moderately
     male systemprostate  moderately
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines several cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C2 domain
  • a PI3K/PI4K domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Pik3cb
    ortholog to murine Pik3cb
    Homologene
    FAMILY
  • PI3/PI4-kinase family
  • CATEGORY enzyme , signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing a role in RAS activation
  • playing a key role in regulating the formation and stability of integrin alpha(IIb)beta(3) adhesion bonds, necessary for shear activation of platelets
  • with PIK3CA, regulate S-phase entry
  • critical for cell growth and survival
  • plays an essential role in GP6-mediated platelet aggregation and Akt activation
  • positively controls LPS-induced IL12 production through the JNK1-dependent pathway in human macrophages and dendritic cells
  • PIK3R1 and PIK3CB are essential for androgen-stimulated androgen receptor transactivation, and their aberrant expression or activation might play an important role in prostate cancer progression
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text regulation of progression through cell cycle
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene important new target for antithrombotic therapy
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    PI3K inhibitor that is capable of inhibiting the p110beta isoform (PIK3CB) can treat patients with PTEN-negative tumors
    ANIMAL & CELL MODELS