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FLASH GENE

Symbol

PIK3CB

contributors: mct/npt/pgu - updated : 19-04-2016

HGNC name	phosphoinositide-3-kinase, catalytic, beta polypeptide
HGNC id	8976

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q22.3      Physical location : 138.374.232 - 138.478.185
Synonym name	PtdIns-3-kinase p110
	PI3-kinase p110 subunit beta
	catalytic phosphatidylinositol 3-kinase beta
Synonym symbol(s)	PIK3C1, PI3K, PI3Kbeta, p110-BETA, DKFZp779K1237, MGC133043, PI3KCB, PIK3C1
EC.number	2.7.1.153

DNA

TYPE	functioning gene
STRUCTURE	103.96 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006219 22 - 3213 NP_006210 - 1070 - 1993 8246984

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       moderately Digestive intestine small intestine     moderately   intestine large intestine colon   moderately   mouth tongue     highly Endocrine thyroid         Nervous brain       moderately Reproductive female system breast mammary gland   moderately   female system uterus cervix   moderately   male system prostate     moderately Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Epithelial secretory glandular endocrine   Muscular striatum skeletal

cell lineage
cell lines	several cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	C2 domain
	a PI3K/PI4K domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	ortholog to rattus Pik3cb
	ortholog to murine Pik3cb

Homologene

FAMILY

PI3/PI4-kinase family

CATEGORY

enzyme , signaling , receptor membrane

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	playing a role in RAS activation
	playing a key role in regulating the formation and stability of integrin alpha(IIb)beta(3) adhesion bonds, necessary for shear activation of platelets
	with PIK3CA, regulate S-phase entry
	critical for cell growth and survival
	plays an essential role in GP6-mediated platelet aggregation and Akt activation
	positively controls LPS-induced IL12 production through the JNK1-dependent pathway in human macrophages and dendritic cells
	PIK3R1 and PIK3CB are essential for androgen-stimulated androgen receptor transactivation, and their aberrant expression or activation might play an important role in prostate cancer progression

CELLULAR PROCESS	cell cycle, progression

PHYSIOLOGICAL PROCESS

coagulation/hemostasis

text	regulation of progression through cell cycle

PATHWAY

metabolism

signaling

signal transduction

a component

heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit

INTERACTION

DNA

RNA

small molecule

protein

CRKL mediates PIK3CB-dependent PI3K signaling in PTEN-deficient cancer cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	important new target for antithrombotic therapy
Marker
Therapy target
	System Type Disorder Pubmed cancer     PI3K inhibitor that is capable of inhibiting the p110beta isoform (PIK3CB) can treat patients with PTEN-negative tumors

ANIMAL & CELL MODELS