protein
| associates with clathrin and thus provides a link between receptor mediated intracellular signalling and clathrin coated vesicle transport |
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ITSN associated with PI3KC2B on a subset of endomembrane vesicles and enhanced both basal and growth factor-stimulated PI3KC2B activity, resulting in AKT activation |
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associates with clathrin and thus provides a link between receptor mediated intracellular signalling and clathrin coated vesicle transportis activated by the T-cell receptor (TCR) and is critical for KCNN4 channel activation |
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TRIM27 functions as an E3 ligase and mediates lysine 48 polyubiquitination of PI3KC2B, leading to a decrease in PI3K enzyme activity |
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TRIM27 functions as an E3 ligase to ubiquitinate and inhibit PI3KC2B kinase activity |
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is also essential for FCER1A activation of KCNN4 and Ca2+ influx in mast cells and TRIM27 plays a similar role to negatively regulate KCNN4 channel activity and FCER1A activation of mast cells |