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FLASH GENE
Symbol PIK3C2B contributors: mct - updated : 03-09-2015
HGNC name phosphoinositide-3-kinase, class 2, beta polypeptide
HGNC id 8972
Location 1q32.1      Physical location : 204.391.758 - 204.459.474
Synonym name
  • PI3K-C2beta
  • PTDINS-3-kinase C2
  • Synonym symbol(s) C2-PI3K
    EC.number 2.7.1.137/ 2.7.1.154
    DNA
    TYPE functioning gene
    STRUCTURE 67.00 kb     34 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    C1orf37 1q31.1 chromosome 1 open reading frame 37 PPFIA4 1q32.1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 MYOG 1q31-q41 myogenin (myogenic factor 4) ADORA1 1q32.1 adenosine A1 receptor MYBPH 1q32.1 myosin binding protein H CHI3L1 1q31-q32 chitinase 3-like 1 (cartilage glycoprotein-39) CHIT1 1q31-q32 chitinase 1 (chitotriosidase) LOC388729 1 LOC388729 BTG2 1q32 BTG family, member 2 FMOD 1q32.1 fibromodulin ATP2B4 1q32 ATPase, Ca++ transporting, plasma membrane 4 MGC5457 1q32.1 hypothetical protein MGC5457 LAX 1q32.1 hypothetical protein FLJ20340 KIAA0663 1q32.1 hypothetical protein FLJ20340 SNRPE 1q32 small nuclear ribonucleoprotein polypeptide E LOC391155 1 similar to KRT8 protein FLJ40343 1q32.1 hypothetical protein FLJ40343 SOX13 1q31.3-q32.1 SRY (sex determining region Y)-box 13 FLJ10761 1q32.1 putative ethanolamine kinase REN 1q32 renin KISS1 1q32 KiSS-1 metastasis-suppressor FLJ42654 1q32.1 FLJ42654 protein PEPP3 1q32.1 phosphoinositol 3-phosphate-binding protein-3 PPP1R15B 1q32.1 protein phosphatase 1, regulatory (inhibitor) subunit 15B PIK3C2B 1q32 phosphoinositide-3-kinase, class 2, beta polypeptide MDM4 1q32 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) GAC1 NFASC 1q32.1 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) CNTN2 1q32.1 contactin 2 (axonal) LOC388730 1 similar to RIKEN cDNA 4930429O20 RBBP5 1q32 retinoblastoma binding protein 5 KIAA0472 HUCEP11 1q32.1 retinoblastoma binding protein 5 SNARK 1q32 Homo sapiens likely ortholog of rat SNF1/AMP-activated protein kinase (SNARK), mRNA. FLJ10748 1q32.1 hypothetical protein FLJ10748 LOC93273 1q32.1 hypothetical protein LOC93273 PCTK3 1q31-q32 PCTAIRE protein kinase 3 DKFZp761N1114 1q32.1 hypothetical protein DKFZp761N1114
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemplacenta  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a universal Ca2+ binding domain (C2)
  • proline-rich motifs within the N terminus mediating the association with activated EGF receptor involving the GRB2 adaptor
  • HOMOLOGY
    Homologene
    FAMILY PI3/PI4-kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    basic FUNCTION
  • may be involved in EGF and PDGF signaling cascades
  • plays a critical role in T-cell activation
  • both PI3KC2B and TRIM27 play critical but opposite roles in FCER1A-stimulated activation of KCNN4, Ca2+ influx, degranulation, and cytokine production in bone marrow mast cells
  • PI3KC2B and PIK3CG control distinct steps involved in cell migration supporting the hypothesis that different PI3Ks regulate distinct cellular processes
  • novel role for PI3KC2B in human neuroblastoma tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    calcium, magnesium, or manganese
    protein
  • associates with clathrin and thus provides a link between receptor mediated intracellular signalling and clathrin coated vesicle transport
  • ITSN associated with PI3KC2B on a subset of endomembrane vesicles and enhanced both basal and growth factor-stimulated PI3KC2B activity, resulting in AKT activation
  • associates with clathrin and thus provides a link between receptor mediated intracellular signalling and clathrin coated vesicle transportis activated by the T-cell receptor (TCR) and is critical for KCNN4 channel activation
  • TRIM27 functions as an E3 ligase and mediates lysine 48 polyubiquitination of PI3KC2B, leading to a decrease in PI3K enzyme activity
  • TRIM27 functions as an E3 ligase to ubiquitinate and inhibit PI3KC2B kinase activity
  • is also essential for FCER1A activation of KCNN4 and Ca2+ influx in mast cells and TRIM27 plays a similar role to negatively regulate KCNN4 channel activity and FCER1A activation of mast cells
  • cell & other
    REGULATION
    activated by GRB2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a potential new pharmacologic target to treat IgE-mediated disease
  • Marker
    Therapy target
    ANIMAL & CELL MODELS