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FLASH GENE
Symbol PIH1D1 contributors: mct/pgu - updated : 20-09-2014
HGNC name PIH1 domain containing 1
HGNC id 26075
Location 19q13.33      Physical location : 49.949.549 - 49.955.115
Synonym name nucleolar protein 17 homolog
Synonym symbol(s) FLJ20643, NOP17, PIH1
DNA
TYPE functioning gene
STRUCTURE 5.71 kb     9 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1256 32.2 290 - 2005 15670595
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta  highly Homo sapiens
Respiratorylung   highly Homo sapiens
Visualeye   lowly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a domain in PIH1D1 specific for binding CK2 phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY
  • PIH1 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required either for nucleolar retention or for the proper assembly of the box C/D snoRNP
  • may also function as a novel modulator of apoptosis pathway with RUVBL2
  • with binding to RPAP3 and WDR92, regulates apoptosis, indicating the possibility that the function of the R2TP/prefoldin-like complex (containing WDR92) may be related to the regulation of apoptosis in mammalian cells
  • is a positive regulator of rRNA genes and is of great importance for the recovery of cells from nutrient starvation and the transition to glucose-induced exponential growth
  • may have an important role in MTOR regulation in breast cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • chaperon complex R2TP composed of Pontin, Reptin, RPAP3, and PIH1D1 and prefoldin-like complex (including WDR92) in mammalian cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with both RPAP3 and WDR92
  • RPAP3, Pontin, Reptin, and PIH1D1 were identified as WDR92 binding proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS