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FLASH GENE
Symbol PIGU contributors: mct - updated : 11-09-2019
HGNC name phosphatidylinositol glycan anchor biosynthesis, class U
HGNC id 15791
Corresponding disease
GPIBD20 glycosylphosphatidylinositol biosynthesis defect 20
Location 20q11.22      Physical location : 33.148.346 - 33.265.089
Synonym name
  • phosphatidylinositol-glycan biosynthesis, class U protein
  • CDC91 cell division cycle 91-like 1 (S. cerevisiae)
  • GPI transamidase subunit
  • CDC91 cell division cycle 91-like 1
  • Synonym symbol(s) MGC40420, CDC91L1, GAB1
    DNA
    TYPE functioning gene
    STRUCTURE 116.74 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1833 - 435 - 2003 12802054
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Endocrinepancreas    
    Nervousbrain    
     nerve   highly
     nervecranial nerve  highly
    Reproductivemale systemprostate   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    nine putative transmembrane domains
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Cdc91
    homolog to Drosophila CG13090
    homolog to C.elegans F42G8.6
    Homologene
    FAMILY PIGU family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may function in cell division control
  • may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI
  • fifth component of GPI transamidase that may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI
  • plays a role in the development of bladder urothelial cell carcinoma
  • might be involved in cell cycle-related biological processes in hepatocellular carcinoma (HCC)
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with PIGK/GPI8, PIGS, PIGT and GPAA1/GAA1
  • critical subunit of the glycosylphosphatidylinositol transamidase (GPI-T) complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIGT, PIGU, and GPAA1 may form a core complex associated by PIGS, and these four subunits may stabilize PIGK, triggering GPI anchoring reactions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GPIBD20
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    and amplified in bladder cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • overexpressed PIGU was an independent predictor for poor survival in hepatocellular carcinoma (HCC) patients
  • might be a potential biomarker for prediction of recurrence in bladder cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    therapeutic target in bladder cancer
    ANIMAL & CELL MODELS