Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PIGU

contributors: - updated : 05-09-2007

HGNC name	phosphatidylinositol glycan anchor biosynthesis, class U
HGNC id	15791

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q11.21      Physical location : 33.148.346 - 33.265.089
Synonym name	phosphatidylinositol-glycan biosynthesis, class U protein
	CDC91 cell division cycle 91-like 1 (S. cerevisiae)
	GPI transamidase subunit
	CDC91 cell division cycle 91-like 1
Synonym symbol(s)	MGC40420, CDC91L1, GAB1

DNA

TYPE	functioning gene
STRUCTURE	116.00 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Endocrine pancreas         Nervous brain           nerve       highly   nerve cranial nerve     highly Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

nine putative transmembrane domains

HOMOLOGY

interspecies	homolog to yeast S.cerevisiae Cdc91
	homolog to Drosophila CG13090
	homolog to C.elegans F42G8.6

Homologene

FAMILY

PIGU family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION	may function in cell division control
	may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI
	fifth component of GPI transamidase that may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI

CELLULAR PROCESS	cell cycle

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with PIGK/GPI8, PIGS, PIGT and GPAA1/GAA1

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   and amplified in bladder cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS