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FLASH GENE
Symbol PIGR contributors: mct - updated : 07-12-2011
HGNC name polymeric immunoglobulin receptor
HGNC id 8968
Location 1q32.2      Physical location : 207.101.868 - 207.119.811
DNA
TYPE functioning gene
STRUCTURE 17.94 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4295 - 764 - 2004 14644095
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine     Homo sapiens
 liver    
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryolfactory  
Membranesensory   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY immunoglobulin superfamily
CATEGORY receptor
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
text secreted
basic FUNCTION
  • immunoglobulin polymeric (poly-Ig) receptor
  • transmembrane secretory complement
  • FCAMR and PIGR have different roles in intestinal immunity
  • plays a role in the induction of epithelial-mesenchymal transition (EMT)
  • potential link between hepatitis B virus-derived hepatitis and hepatocellular carcinoma metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text transporting polymerized Ig at mucosal surface
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • carboxy terminal domains of IGM and IGA
  • secreted component cleaved by proteinases increased by neutrophils through NF-kappa B and p38-mitogen activated protein-kinase-dependent mechanisms
  • interaction between RAB3D and PIGR implicated in trafficking through regulated secretory vesicles in lacrimal gland acinar cells
  • in addition to its role in transcytosis, MAL2 also regulates PIGR delivery from the Golgi to the plasma membrane
  • cell & other
  • mediating invasion of Streptococcus pneumoniae into the epithelium yhrough ecodomainsD3 and D4
  • REGULATION
    Other transcription enhanced by upstream stimulatory factor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker prognostic biomarker for hepatocellular carcinoma
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    potential therapeutic target in hepatocellular carcinoma
    ANIMAL & CELL MODELS