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FLASH GENE
Symbol PIGR contributors: mct - updated : 07-12-2011
HGNC name polymeric immunoglobulin receptor
HGNC id 8968
Location 1q32.2      Physical location : 207.101.868 - 207.119.811
DNA
TYPE functioning gene
STRUCTURE 17.94 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
MAPPING cloned Y linked Y status confirmed
Physical map
LOC391156 1 LOC391156 FNBP2 1q31.3 formin binding protein 2 IKBKE 1q32.1 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon RASSF5 1q32.1 Ras association (RalGDS/AF-6) domain family 5 LGTN 1q31-q32 ligatin DYRK3 1q32 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 MAPKAPK2 1q32 mitogen-activated protein kinase-activated protein kinase 2 IL10 1q31.3-q32.1 interleukin 10 IL19 1q32.2 interleukin 19 IL20 1q32 interleukin 20 IL24 1q32 interleukin 24 TOSO 1q32.1 regulator of Fas-induced apoptosis PIGR 1q32 polymeric immunoglobulin receptor FKSG87 1q32.1 FKSG87 protein LOC387623 1 hypothetical gene supported by NM_024115 SARG 1q32.1 specifically androgen-regulated protein DKFZp451J1719 1q32.1 hypothetical DKFZp451J1719 PFKFB2 1q31 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 C4BPB 1q32 complement component 4 binding protein, beta C4BPA 1q32 complement component 4 binding protein, alpha LOC343024 1q32.1 similar to C4BP alpha chain precursor - rabbit C4BPAL2 1q32 complement component 4 binding protein, alpha-like 2 DAF 1q32 decay accelerating factor for complement (CD55, Cromer blood group system) FLJ13310 1q32.1 hypothetical protein FLJ13310 CR2 1q32 complement component (3d/Epstein Barr virus) receptor 2 CR1 1q32 complement component (3b/4b) receptor 1, including Knops blood group system
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4295 - 764 - 2004 14644095
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine     Homo sapiens
 liver    
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryolfactory  
Membranesensory   
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY immunoglobulin superfamily
CATEGORY receptor
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
text secreted
basic FUNCTION
  • immunoglobulin polymeric (poly-Ig) receptor
  • transmembrane secretory complement
  • FCAMR and PIGR have different roles in intestinal immunity
  • plays a role in the induction of epithelial-mesenchymal transition (EMT)
  • potential link between hepatitis B virus-derived hepatitis and hepatocellular carcinoma metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text transporting polymerized Ig at mucosal surface
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • carboxy terminal domains of IGM and IGA
  • secreted component cleaved by proteinases increased by neutrophils through NF-kappa B and p38-mitogen activated protein-kinase-dependent mechanisms
  • interaction between RAB3D and PIGR implicated in trafficking through regulated secretory vesicles in lacrimal gland acinar cells
  • in addition to its role in transcytosis, MAL2 also regulates PIGR delivery from the Golgi to the plasma membrane
  • cell & other
  • mediating invasion of Streptococcus pneumoniae into the epithelium yhrough ecodomainsD3 and D4
  • REGULATION
    Other transcription enhanced by upstream stimulatory factor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker prognostic biomarker for hepatocellular carcinoma
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    potential therapeutic target in hepatocellular carcinoma
    ANIMAL & CELL MODELS