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FLASH GENE
Symbol PIGQ contributors: np/ - updated : 05-09-2006
HGNC name phosphatidylinositol glycan anchor biosynthesis, class Q
HGNC id 14135
Location 16p13.3      Physical location : 620.003 - 634.108
Synonym name
  • phosphatidylinositol glycan, class Q
  • N-acetylglucosaminyl transferase componant GPI1
  • c407A10.1 (GPI1 (N-acetylglucosaminyl transferase component))
    • Synonym symbol(s) GPI1, HGPI1, c407A10.1, MGC12693
    EC.number 2.4.1.198
    DNA
    TYPE functioning gene
    STRUCTURE 14.11 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    RGS11 16p13.3 regulator of G-protein signalling 11 ARHGDIG 16p13.3 Rho GDP dissociation inhibitor (GDI) gamma AXIN1 16p13.3 axin 1 MRPL28 16p13.3 mitochondrial ribosomal protein L28 TMEM8 16p13.3 transmembrane protein 8 (five membrane-spanning domains) LOC388197 16 hypothetical gene supported by BC028568 NME4 16p13 non-metastatic cells 4, protein expressed in DECR2 16p13.3 2,4-dienoyl CoA reductase 2, peroxisomal Rab11-FIP3 16p13.3 eferin SOLH 16p13.3 small optic lobes homolog (Drosophila) LOC146325 16p13.3 similar to hypothetical protein FLJ13841 FLJ36208 16p13.3 hypothetical protein FLJ36208 PIGQ 16p13.3 phosphatidylinositol glycan, class Q RAB40C 16p13.3 RAB40C, member RAS oncogene family WFIKKN 16p13.3 RAB40C, member RAS oncogene family MGC13114 16p13.3 hypothetical protein MGC13114 LOC388198 16 LOC388198 MGC15416 16p13.3 hypothetical protein MGC15416 KIAA1924 16p13.3 hypothetical protein KIAA1924 LOC197336 16p13.3 similar to RIKEN cDNA 3230401M21 [Mus musculus] ARHT2 16p13.3 ras homolog gene family, member T2 RHBDL1 16p13.3 rhomboid, veinlet-like 1 (Drosophila) STUB1 16p13.3 STIP1 homology and U-Box containing protein 1 LOC339123 16p13.3 similar to RIKEN cDNA 2610003J06 DKFZp434F054 16p13.3 hypothetical protein DKFZp434F054 MGC33974 16p13.3 hypothetical protein MGC33974 MGC2601 16p13.3 hypothetical protein MGC2601 MGC2494 16p13.3 hypothetical protein MGC2494 FLJ34512 16p13.3 hypothetical protein FLJ34512 HAGHL 16p13.3 hydroxyacyl glutathione hydrolase-like NARFL 16p13.3 nuclear prelamin A recognition factor-like
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 2921 67.9 581 - 1998 9463366
    10 splicing 2878 83.6 760 - 1998 9463366
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage hematopoietic cells lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • transmembrane domain
  • potential tyrosine phosphorylation site
  • several hydrophobic regions
  • a potential tyrosine phosphorylation site in the third cytoplasmic loop
    • HOMOLOGY
    interspecies homolog to murine Pigq
    Homologene
    FAMILY
  • PIGQ family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • glycosylphosphatidyl inositol (GPI) anchor biosynthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
  • forming a complex with PIGA, PIGC, PIGH, PIGQ and GAA1, DPM2, not complexing with colocalized PIGL
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS