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FLASH GENE
Symbol PIGO contributors: mct - updated : 20-08-2012
HGNC name phosphatidylinositol glycan, class O
HGNC id 23215
Corresponding disease
HPMRS2 hyperphosphatasia with mental retardation syndrome 2
Location 9p13.3      Physical location : 35.088.689 - 35.096.579
Synonym symbol(s) DKFZp434M222, FLJ00135, MGC3079, MGC20536
DNA
TYPE functioning gene
STRUCTURE 7.91 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2934 - 672 - 2012 22683086
11 splicing 4087 118 1089 - 2012 22683086
12 splicing 2482 - 672 - 2012 22683086
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestineduodenum  
Lymphoid/Immunespleen    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies homolog to murine Pigo
Homologene
FAMILY type I phosphodiesterase/nucleotide pyrophosphatase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • involved in GPI-anchor biosynthesis, transferring ethanolamine phosphate to the third mannose in GPI (glycosylphosphatidylinositol
  • is potentially essential for GPI anchoring of GPI-APs alkaline phosphatase, CD59, and PLAUR
  • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein forming a complex with PIGF
    cell & other
    REGULATION
    Other stabilized by PIGF
    ASSOCIATED DISORDERS
    corresponding disease(s) HPMRS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS