Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PIGK contributors: - updated : 07-07-2007
HGNC name phosphatidylinositol glycan, class K
HGNC id 8965
Location 1p31.1      Physical location : 77.554.668 - 77.685.132
Synonym symbol(s) GPI8,HGPI8
DNA
TYPE functioning gene
STRUCTURE 127.00 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC22773 1p31.1 hypothetical protein MGC22773 FPGT 1p31.1 fucose-1-phosphate guanylyltransferase CARK DKFZp547I048 1p31.1 hypothetical protein DKFZp547I048 CRYZ 1p31-p22 crystallin, zeta (quinone reductase) LOC388640 1 similar to crystallin, zeta; NADPH:quinone reductase LOC127253 1p31.1 hypothetical protein BC009514 LOC148864 1p31.1 similar to LIM homeo domain transcription factor MGC34032 1p31.1 hypothetical protein MGC34032 LOC388641 1 LOC388641 LOC343221 1p31.1 similar to KIAA0433 protein ACADM 1p31 acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain DLSTP 1p31 dihydrolipoamide S-succinyltransferase pseudogene (E2 component of 2-oxo-glutarate complex) RABGGTB 1p31 Rab geranylgeranyltransferase, beta subunit MSH4 1p31 mutS homolog 4 (E. coli) ASB17 1p31.1 ankyrin repeat and SOCS box-containing 17 SIAT7C 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C LOC388642 1 similar to Triosephosphate isomerase (TIM) LOC388643 1 LOC388643 SIAT7E 1p31.1 sialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) E LOC256483 1p31.1 hypothetical LOC256483 PIGK 1p31.1 phosphatidylinositol glycan, class K AK5 1p31 adenylate kinase 5 DKFZP564I052 USP33 1p31.1 ubiquitin specific protease 33 FLJ35093 1p31.1 FLJ35093 protein LOC91624 FUBP1 1p31.1 far upstream element (FUSE) binding protein 1 DNAJB4 1p31.1 DnaJ (Hsp40) homolog, subfamily B, member 4 LOC339425 1p31.1 similar to Nit protein 2 GIPC2 1p31.1 PDZ domain protein GIPC2 LOC388644 1 hypothetical gene supported by AK091757 PTGFR 1p31.1 prostaglandin F receptor (FP) C1orf29 1p31.1 chromosome 1 open reading frame 29 IFI44 1p31.1 interferon-induced protein 44 LOC343295 1p31.1 similar to Nuclear protein SkiP (Ski-interacting protein) (SNW1 protein) (Nuclear receptor coactivator NCoA-62) ELTD1 1p33-p32 EGF, latrophilin and seven transmembrane domain containing 1 LOC149050 1p31.1 similar to phosphoserine aminotransferase isoform 1 LOC343296 1p31.1 similar to Alcohol dehydrogenase class III chi chain (Glutathione-dependent formaldehyde dehydrogenase) (FDH) LOC391049 1 similar to Rda288-prov protein COX6A1P 1p31.1 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroid
Blood/Hematopoieticgranulocyte
Lymphoid/Immunelymphocyte
cell lineage hematopoietic stem cell
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a signal peptide a peptidase C13 domain,a transmembrane segment
HOMOLOGY
interspecies homolog to yeast GPI8
Homologene
FAMILY peptidase family C13
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
basic FUNCTION
  • phosphatidylinositol glycan,class K,glycosylphosphatidyl inositol transamidase,final step in GPI donnors anchoring in which preassembled GPI are subtituted for C terminal signal sequences in nascent polypeptides
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complexing with PIGS and PIGT and GPAA1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with GPAA1 for GPI anchor attachment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS