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FLASH GENE
Symbol PIGF contributors: mct - updated : 06-01-2011
HGNC name phosphatidylinositol glycan anchor biosynthesis, class F
HGNC id 8962
Location 2p21      Physical location : 46.808.413 - 46.844.251
Synonym name
  • phosphatidylinositol glycan, class F
  • GPI11 homolog
  • Synonym symbol(s) MGC33136, MGC32646
    DNA
    TYPE functioning gene
    STRUCTURE 35.84 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    D2LIC 2p25.1-p24.1 dynein 2 light intermediate chain ABCG5 2p21 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) ABCG8 2p21 ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) LRPPRC 2p21 leucine-rich PPR-motif containing PPM1B 2p22,1 protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform LOC391371 2 similar to 60S RIBOSOMAL PROTEIN L12 SLC3A1 2p16.3 solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 FLJ23451 2p22.1 hypothetical protein FLJ23451 SIX3 2p21-p16 sine oculis homeobox homolog 3 (Drosophila) LOC388944 2 LOC388944 SIX2 2p16-p15 sine oculis homeobox homolog 2 (Drosophila) LOC151111 2p21 hypothetical LOC151111 FLJ10379 2p21 hypothetical protein FLJ10379 PRKCE 2p21 protein kinase C, epsilon EPAS1 2p21-p26 endothelial PAS domain protein 1 LOC388945 2 LOC388945 LOC388946 2 LOC388946 ATP6V1E2 2p21 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 2 ARHQ 2p21 ras homolog gene family, member Q PIGF 2p16 phosphatidylinositol glycan, class F CRIPT 2p21 phosphatidylinositol glycan, class F LOC388947 2 LOC388947 SOCS5 2p21 suppressor of cytokine signaling 5 LOC388948 2 hypothetical gene supported by BC062774 MCFD2 TTC7 2p21 tetratricopeptide repeat domain 7 FLJ40172 2p21 hypothetical protein FLJ40172 CALM2 2p21.3-p21.1 calmodulin 2 (phosphorylase kinase, delta) TACSTD1 2p21 tumor-associated calcium signal transducer 1 MSH2 2p22-p21 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) KCNK12 2p22-p21 potassium channel, subfamily K, member 12 LOC285053 2p21 similar to ribosomal protein L18a; 60S ribosomal protein L18a LOC391372 2 similar to Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (P18) MSH6 2p16 mutS homolog 6 (E. coli) FBXO11 2p21-p16 F-box only protein 11 HTLF 2p21 human T-cell leukemia virus enhancer factor LOC129285 2p21 smooth muscle myosin heavy chain 11 isoform SM1-like SALF 2p16.3 smooth muscle myosin heavy chain 11 isoform SM1-like SBLF 2p16.3 stoned B-like factor ALF 2p16.3 stoned B-like factor LHCGR 2p21 luteinizing hormone/choriogonadotropin receptor LOC391373 2 similar to C-terminal binding protein 2 isoform 2; ribeye FSHR 2p16 follicle stimulating hormone receptor LOC339793 2p21 similar to PRO1094
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1057 24.9 219 - 2000 10781593
    7 splicing 1162 23.4 206 - 2000 10781593
    alternative exon in the 3'coding region
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     granular cell
    Blood/Hematopoieticerythrocyte
    Lymphoid/ImmuneB cell
    cell lineage hematopoietic
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
  • PIGF family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • glycosyl-phosphatidylinositol (GPI), anchor synthesis, class F
  • involved in transferring the third mannose of the GPI anchor, the first step of the synthesis
  • PIGF is a direct and physiologically relevant transcriptional target of FOXD1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
  • GPI7 forms a protein complex with PIGF and is involved in the H7-to-H8 conversion
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PIG-O
  • PIGG is the second partner of PIGF and involved in modification of glycosylphosphatidylinositol
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS