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FLASH GENE
Symbol PID1 contributors: mct - updated : 22-10-2011
HGNC name phosphotyrosine interaction domain containing 1
HGNC id 26084
Location 2q36.3      Physical location : 229.888.689 - 230.136.057
Synonym name
  • PTB-containing, cubilin and LRP1-interacting protein
    • Synonym symbol(s) NYGGF4, HMFN2073, FLJ20701, PCLI1
    DNA
    TYPE functioning gene
    STRUCTURE 247.37 kb     4 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 28 250 predominantly in adipose, also in heart and skeletal muscle 2006 16815647
    4 - 2837 28 248 - 2006 16815647
    - - - - 168 - 2006 16815647
    3 - 2626 - 217 - 2006 16815647
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		phosphotyrosine-binding domain (PTB)
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • increasing proliferation of preadipocytes
  • regulates the functions of IR-1 and AKT1, decreases SLC2A4 translocation and reduces glucose uptake in response to insulin
  • may be an important mediator in the development of obesity-related insulin resistance
  • involved in obesity-associated insulin resistance
  • regulatory function in adipocyte insulin sensitivity
  • potential role in glucose homeostasis and the development of insulin resistance in obesity
    • CELLULAR PROCESS cell cycle, checkpoint
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other adipocytes and preadipocytes cells
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3K/AKT insulin pathway
    constitutional     --over  
    in the adipose tissue of obese subjects
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS