SUBCELLULAR LOCALIZATION
| plasma membrane,junction,adherens
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| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic,granule
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| intracellular,cytoplasm,cytoskeleton
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text
| concentrated in perinuclear region and in excitatory synapses |
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localised at adherens junctions in epithelial cells |
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diffuse cytoplasmic localization, but it clusters on vesicle-like structures that colocalize with the trans-Golgi network marker TGN38 upon deletion of either the ACT or PDZ domain |
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localise to the Golgi apparatus and the proacrosomal granules that are transported in the acrosome |
basic FUNCTION
| Ca2+-binding protein, that may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins |
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acting as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner |
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protein kinase binding protein, potentially involved in vesicular trafficking |
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playing an essential role in the control of synaptic transmission by GRM7 |
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may regulate ACCN3-ACCN2 heteromeric cation channel |
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involved in the clustering of various receptors, possibly by acting at the receptor internalization level |
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could be involved in the regulation of both adherens and tight junctions in epithelial cells |
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postsynaptic Ca2+-binding protein that provides a direct mechanistic link between N-methyl-D-aspartate receptor-mediated Ca2+ influx and AMPAR endocytosis |
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inhibiting potently Arp2/3-mediated actin polymerization |
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being critical for a specific form of vesicle trafficking, and also for the development of neuronal architecture |
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plays a crucial role in the response to oxygen and glucose deprivation that results in altered synaptic transmission and neuronal death |
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having a role in synaptic plasticity established most clearly in the cerebellum, where long-term depression at multiple synapses requires intact PICK1 function |
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its function is specific to NMDAR-dependent long-term depression(LTD) and the underlying AMPAR trafficking |
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implicated in the regulation of AMPAR trafficking underlying several forms of synaptic plasticity, and is essential for the intracellular retention of AMPA receptors underlying long-term depression |
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AMPA-type glutamate receptors (AMPARs) mediate the majority of fast excitatory neurotransmission in the mammalian central nervous system |
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developmentally regulated role for PICK1 in hippocampal synaptic plasticity and learning, and in normal brain function |
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regulates spine size in hippocampal neurons via inhibition of the Arp2/3 complex |
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functions as a crucial factor in both structural and functional plasticity |
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important role of PICK1 in inactivity-induced synaptic scaling by regulating the subunit composition, abundance, and trafficking of GluA2-containing AMPARs |
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KIRREL, KIRREL2, KIRREL3 and PICK1 synergistically regulate cell recognition and contact formation |
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non-neural function of PICK1 is an important negative regulator of TGFB1 signaling |
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may not only affect glutamatergic neurotransmission by its regulatory effect on glutamate receptors but may also affect neuronal excitability via an increased SLC2A1-mediated leak current |
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is involved in regulating the cell-cell junction in epithelial cells, and this may influence therapeutic strategy decisions with regards to cell adhesion molecules in metastatic disease |
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functions in vesicle biogenesis and is necessary to maintain normal vesicle numbers and size |
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modular scaffold implicated in synaptic receptor trafficking |
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is crucial for vesicle trafficking, and its deficiency in sperm cells leads to abnormal vesicle trafficking from the Golgi to the acrosome |
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PDZ domain-containing protein, known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface |