protein
| growth factor independent 1 transcription repressor, GFI1  |
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signal transducer and activator of transcription 3 (acute-phase response factor), STAT3  |
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high-mobility group (nonhistone chromosomal) protein isoform I-C, HMGI-C  |
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transcriptional intermediary factor 2, TIF2  |
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microphthalmia transcription factor, MITF  |
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AT motif-binding factor 1, ATBF1  |
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TRIM8 interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL6-dependent activation of STAT3  |
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v-rel reticuloendotheliosis viral oncogene homolog A (avian), RELA  |
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mineralocorticoid receptor, MR  |
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TATA-binding protein, TBP  |
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SERPINE1 mRNA binding protein 1, SERBP1  |
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tripartite motif-containing 32, TRIM32  |
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interaction between ZMIZ2 and PIAS proteins with higher preference for PIAS3 |
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is a novel interaction partner of ERBB4 soluble intracellular domain (ICD)  |
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PIAS3-mediated SUMOylation of endogenous RELA was induced by NFKB1 activation thus forming a negative regulatory loop ( |
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TP ;PIAS3 interaction through the 1-52 amino acid region of TP53, reduces TP53& |
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8209;MDM2 complex formation, which not only increases the half-life of TP53, but also its transactivation of target genes  |
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PIAS3 is a transcriptional corepressor of KLF1 for at least a subset of its target genes during erythropoiesis |
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is the only member of the PIAS family that is indispensable for ATR activation  |
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PIAS3 physically associated with HIF1A, and PIAS3 enhances the transcriptional activity of HIF1A by increasing its protein stability  |
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is a negative regulator of STAT3 activity  |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
significantly lower, in women with endometriosis compared to women without endometriosis, and attenuation of PIAS3 causes likely aberrant activation of STAT3 in endometriosis, leading to inflammatory changes that may impair fertility or cause pain  | tumoral
|  
|  
| --low
|  
|
is more negatively correlated with STAT3 activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome  | tumoral
|  
|  
| --low
|  
|
in malignant mesothelioma is associated with increased STAT3 activation and poor patient survival  | |