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FLASH GENE

Symbol

PIAS2

contributors: mct/npt - updated : 14-03-2017

HGNC name	protein inhibitor of activated STAT, 2
HGNC id	17311

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	18q21.1      Physical location : 44.392.060 - 44.497.466
Synonym name	Msx-interacting zinc finger
	Myc-associated zinc-finger protein 1
	zinc finger, MIZ-type containing 4
	DAB2-interacting protein
	PIAS-NY protein
	E3 SUMO-protein ligase PIAS2
Synonym symbol(s)	PIASX, MIZ1, SIZ2, PIASX-BETA, PIASX-ALPHA, ZMIZ4, ARIP3, DIP, MGC102682

DNA

TYPE	functioning gene
STRUCTURE	105.41 kb     14 Exon(s)

regulatory sequence	Promoter
text structure	proximal promoter forming a major DNA-protein complex containing Sp1, Sp2, and Sp3 transcription factors

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_173206 13 - 1919 NP_775298 - 572 - Nishida, Saito (2009) also called isoform alpha bound UBC9, the E2 enzyme for SUMO-1, in a RING finger-like domain-dependent manner modulating the AR-dependent transactivation, which, at least in part, can be attributed to their SUMO-E3 activity toward AR NM_004671 14 - 2360 NP_004662 68.2 621 - Nishida, Saito (2009) also called isoform beta

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     highly Skeleton axial skull

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	progenitor cells of orofacial skeletal structure

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to S.cerevisiae Nfi-1

Homologene

FAMILY

PIAS family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	positive acting transcription factor
	functioning as a UBL1 (SUMO-E3) ligase
	may function as a co-repressor of STAT4
	acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated (Yang 2006)
	PIAS2 is a POZ-domain transcription factor that regulates cell-cycle arrest and DNA-damage responses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

PIAS2-MEF2A sumoylation signaling link as a key mechanism that orchestrates postsynaptic dendritic claw morphogenesis in the cerebellar cortex and may have novel functions for SUMO E3 ligases in brain development and plasticity (Shalizi 2007)

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	binding MSX2 and enhancing its DNA binding capacity
	modifying MDM2 (sumoylation)
	specific SUMO-E3 ligases for the androgen receptor(AR)
	interaction with BCL6 (BCL6 binds to the BCL2 promoter region by interacting with the transcriptional activator PIAS2 and suppresses PIAS2-induced activation of BCL2 expression) (Saito 2009)
	activities of PIAS2 are altered by its interaction with the POZ-domain transcriptional repressors BCL6 and NACC1, and these interactions have been implicated in tumourigenesis in B-cell lymphomas and in ovarian serous carcinomas

cell & other

REGULATION

repressed by

ribosomal protein L23 (negative regulator of PIAS2-dependent transactivation) (Wanzel 2008)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS