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FLASH GENE
Symbol PIAS2 contributors: mct/npt - updated : 14-03-2017
HGNC name protein inhibitor of activated STAT, 2
HGNC id 17311
Location 18q21.1      Physical location : 44.392.060 - 44.497.466
Synonym name
  • Msx-interacting zinc finger
  • Myc-associated zinc-finger protein 1
  • zinc finger, MIZ-type containing 4
  • DAB2-interacting protein
  • PIAS-NY protein
  • E3 SUMO-protein ligase PIAS2
  • Synonym symbol(s) PIASX, MIZ1, SIZ2, PIASX-BETA, PIASX-ALPHA, ZMIZ4, ARIP3, DIP, MGC102682
    DNA
    TYPE functioning gene
    STRUCTURE 105.41 kb     14 Exon(s)
    regulatory sequence Promoter
    text structure proximal promoter forming a major DNA-protein complex containing Sp1, Sp2, and Sp3 transcription factors
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1919 - 572 - Nishida, Saito (2009)
  • also called isoform alpha
  • bound UBC9, the E2 enzyme for SUMO-1, in a RING finger-like domain-dependent manner
  • modulating the AR-dependent transactivation, which, at least in part, can be attributed to their SUMO-E3 activity toward AR
  • 14 - 2360 68.2 621 - Nishida, Saito (2009)
    also called isoform beta
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  highly
    Skeletonaxialskull   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text progenitor cells of orofacial skeletal structure
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to S.cerevisiae Nfi-1
    Homologene
    FAMILY
  • PIAS family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • positive acting transcription factor
  • functioning as a UBL1 (SUMO-E3) ligase
  • may function as a co-repressor of STAT4
  • acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated (Yang 2006)
  • PIAS2 is a POZ-domain transcription factor that regulates cell-cycle arrest and DNA-damage responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    PIAS2-MEF2A sumoylation signaling link as a key mechanism that orchestrates postsynaptic dendritic claw morphogenesis in the cerebellar cortex and may have novel functions for SUMO E3 ligases in brain development and plasticity (Shalizi 2007)
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding MSX2 and enhancing its DNA binding capacity
  • modifying MDM2 (sumoylation)
  • specific SUMO-E3 ligases for the androgen receptor(AR)
  • interaction with BCL6 (BCL6 binds to the BCL2 promoter region by interacting with the transcriptional activator PIAS2 and suppresses PIAS2-induced activation of BCL2 expression) (Saito 2009)
  • activities of PIAS2 are altered by its interaction with the POZ-domain transcriptional repressors BCL6 and NACC1, and these interactions have been implicated in tumourigenesis in B-cell lymphomas and in ovarian serous carcinomas
  • cell & other
    REGULATION
    repressed by ribosomal protein L23 (negative regulator of PIAS2-dependent transactivation) (Wanzel 2008)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS