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FLASH GENE
Symbol PIAS1 contributors: mct/ - updated : 16-10-2015
HGNC name protein inhibitor of activated STAT, 1
HGNC id 2752
Location 15q23      Physical location : 68.346.571 - 68.480.402
Synonym name
  • androgen receptor interacting protein
  • GU RNA helicase 2 binding protein
  • protein inhibitor of activated STAT, 1
  • DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1
  • zinc finger, MIZ-type containing 3
  • E3 SUMO-protein ligase PIAS1
  • Synonym symbol(s) GBP, GU/RH2, DDXBP1, GU/RH-II, ZMIZ3, MGC141878, MGC141879
    DNA
    TYPE functioning gene
    STRUCTURE 133.84 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure lacking a TATA box
    MAPPING cloned Y linked N status provisional
    Physical map
    MEGF11 15q22.2 MEGF11 protein MGC4562 15q22.2 hypothetical protein MGC4562 FLJ20516 15q22.2 timeless-interacting protein MAP2K1 15q22.1-q22.33 mitogen-activated protein kinase kinase 1 LOC388128 15 similar to ribosomal protein L9; 60S ribosomal protein L9 SNAPC5 15q22.2 small nuclear RNA activating complex, polypeptide 5, 19kDa RPL4 15q22 ribosomal protein L4 FLJ10036 15q22.2 hypothetical protein FLJ10036 MADH6 15q21-q22 MAD, mothers against decapentaplegic homolog 6 (Drosophila) LOC390597 15 similar to leucine zipper-EF-hand containing transmembrane protein 1 MADH3 15q21-q22 MAD, mothers against decapentaplegic homolog 3 (Drosophila) DKFZP586N0721 15q22.31 DKFZP586N0721 protein FLJ11506 15q22.31 hypothetical protein FLJ11506 FLJ12476 15q22.31 hypothetical protein FLJ12476 LOC145853 15q22.31 similar to ENSANGP00000021391 MAP2K5 15q22.2-q22.31 mitogen-activated protein kinase kinase 5 LOC390598 15 similar to RIKEN cDNA C230094B15 LOC388129 15 hypothetical gene supported by BC033162 LOC390599 15 similar to 40S ribosomal protein S15a PIAS1 15q21.3-q22.1 protein inhibitor of activated STAT, 1 MGC4809 15q22.2 serologically defined breast cancer antigen NY-BR-20 CLN6 15q23 ceroid-lipofuscinosis, neuronal 6, late infantile, variant FEM1B 15q22 fem-1 homolog b (C. elegans) ITGA11 15q22.3-q23 integrin, alpha 11 CORO2B 15q22-q23 coronin, actin binding protein, 2B ANP32A 15q22-q23 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A FLJ11722 15q22.31 hypothetical protein FLJ11722 LOC390600 15 similar to RIKEN cDNA 2810413N20 NOX5 15q22.31 NADPH oxidase, EF hand calcium-binding domain 5 SPESP1 15q22.31 sperm equatorial segment protein 1 FLJ33768 15q22.31 hypothetical protein FLJ33768 GLCE 15q22.31 glucuronyl C5-epimerase MPRG 15q22.31 glucuronyl C5-epimerase KIF23 15q22-q23 kinesin family member 23 RPLP1 15q22 ribosomal protein, large, P1 LOC388130 15 LOC388130 LOC388131 15 LOC388131 TLE3 15q22 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2309 71.7 651 - 2009 19136629
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemtestis  highly
    cell lineage spermatogenic cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • putative zinc binding motif and a highly acidic region
  • SAP (SAF-A/B,Acinus and PIAS) domain
  • DNA binding (bihelical) motif
  • a chromatin-binding domain that targets PIAS1 to gene promoters to regulate transcription
  • HOMOLOGY
    interspecies homolog to murine Pias1
    Homologene
    FAMILY
  • PIAS family
  • CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • involved in androgen receptor initiation, function as a UBL1 (SUMO-E3) ligase or as a tightly bound regulator of it toward activation of TP53
  • regulate MEF2A (promotes sumoylation of MEF2A, and protein sumoylation could play a pivotal role in controlling MEF2 transcriptional activity)
  • confers DNA-binding specificity on the MSX1 homeoprotein by regulating its subnuclear localization and proximity to target genes
  • modulating the AR-dependent transactivation, which, at least in part, can be attributed to their SUMO-E3 activity toward AR
  • silencing transcription factor Sp3 through SUMO modification
  • role in ribosomal RNA biogenesis, editing transport and in general transcription
  • modulates transcriptional activation of smooth muscle cells marker genes through cooperative interactions with both SRF and class I bHLH proteins
  • with AIRE interact functionally to regulate the activities of the target genes of AIRE
  • regulating STAT1 signaling upon PRMT1-mediated arginine methylation
  • promotes myogenic differentiation by specifically inhibiting the JAK1/STAT1/STAT3 pathway
  • recruited to DNA damage sites and needed for the productive association of TP53BP1, BRCA1, RNF168 with these regions of damage
  • promotes double strand breaks repair and confers ionizing radiation resistance
  • required for effective ubiquitin-adduct formation at site of DNA damage
  • acts by binding to the FOXP3 promoter to recruit DNA methyltransferases and heterochromatin protein 1 for epigenetic modifications
  • may be an important cofactor that confers specificity in the DNMT-mediated chromatin methylation
  • recruited to STAT1 target gene promoters in a PRMT1- and methylation-dependent manner
  • PIAS1 acts as a "protein inhibitor of activated MYB" in the absence of SUMOylation while, in its presence, PIAS1 behaves as a "protein activator of repressed MYB"
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS
    text ubiquitin degradation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GU binding
  • protein
  • binding to coactivator of androgen and glucocorticoid receptors, corepressor of progesterone receptor, counteracted by other member of the PIAS family (MIZ1, PIAS3)
  • binding to UBL1, TP53
  • inhibiting STAT1 mediated gene activation in response to interferon
  • binding to ATP dependent RNA helicase
  • interacting with Sp3
  • binding UBC9 the E2 enzyme for SUMO-1, in a RING finger-like domain-dependent manner
  • interacting with ESR1
  • negative regulator of NF-kappaB
  • interacting with GRM8
  • interacting with PRMT1 (arginine methylation of PIAS1 is essential for the repressive function of PRMT1 in IFN-dependent transcription and for the recruitment of PIAS1 to STAT1 target gene promoters in the late phase of the IFN response)
  • enhancing the transcriptional repression activity of ZNF133 through the zinc finger motifs
  • targeting activated STAT1 and prevents its binding to DNA
  • ZMYND11 interacts with PIAS1 (a well-characterized SUMO E3 enzyme) and UBE2I (the only SUMO E2 enzyme so far identified) through its distinct regions
  • associated with DNMT3A and DNMT3B in T cells and is required for their recruitment to the FOXP3 gene promoter
  • is a common partner for two cancer-related nuclear factors, MYB and CASP8AP2 (functional cooperation between CASP8AP2 and PIAS1 in the enhancement of MYB activity in active nuclear foci)
  • NDN bound to PIAS1 central domains that are highly conserved among PIAS family proteins and suppressed PIAS1-dependent sumoylation of the substrates STAT1 and PML
  • PIAS1 causes activation or repression of MYB dependent target genes
  • cell & other
  • binds to chromatin to repress transcription
  • REGULATION
    Other activating MAPK8 (JNK1-cJUN-NH2 terminal kinase) and inducing apoptosis
    modifying MDM2 (sumoylation)
    methylated by PRMT1 mediation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    caused promoter demethylation, reduced histone H3 methylation at Lys9, and enhanced promoter accessibility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Pias1&
  • 8722;/&
    8722; mice displayed an increased natural Treg cell population and were resistant to the development of experimental autoimmune encephalomyelitis