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FLASH GENE
Symbol PHOSPHO1 contributors: mct/npt - updated : 07-12-2016
HGNC name phosphatase, orphan 1
HGNC id 16815
Location 17q21.32      Physical location : 47.300.731 - 47.308.128
Synonym name phosphoethanolamine/phosphocholine phosphatase
EC.number 3.1.3.75
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HOXB3 17q21.3 homeo box B3 HOXB4 17q21.3 homeo box B4 HOXB5 17q21.3 homeo box B5 HOXB6 17q21.3 homeo box B6 HOXB7 17q21.3 homeo box B7 HOXB8 17q21.3 homeo box B8 HOXB9 17q21.3 homeo box B9 PRAC 17q21 homeo box B9 HOXB13 17q21.3 homeo box B13 FLJ35808 17q21.33 hypothetical protein FLJ35808 NDP52 17q21.3 hypothetical protein FLJ35808 LOC388399 17 similar to SMT3 suppressor of mif two 3 homolog 2 ATP5G1 17q21.32 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1 FLJ13855 17q21.33 hypothetical protein FLJ13855 EAP30 17q21.33 EAP30 subunit of ELL complex GIP 17q21.31 gastric inhibitory polypeptide IMP-1 17q21.33 IGF-II mRNA-binding protein 1 GALGT2 17q21.3 beta 1,4 N-acetylgalactosaminyltransferase GNGT2 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 NESH 17q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 PHOSPHO1 17q21.32 phosphatase, orphan 1 LOC124871 17q21.33 hypothetical gene LOC124871 KIAA0924 17q21.32 hypothetical gene LOC124871 PHB 17q21.3 prohibitin LOC388400 17 similar to Eukaryotic translation initiation factor 4E (eIF4E) (eIF-4E) (mRNA cap-binding protein) (eIF-4F 25 kDa subunit) NGFR 17q21.31 nerve growth factor receptor (TNFR superfamily, member 16) NXPH3 17q21.31 neurexophilin 3 SPOP 17q22 speckle-type POZ protein SLC35B1 17q21.3-q22 solute carrier family 35, member B1 LOC81558 17q21.33 C/EBP-induced protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 879 - 292 osteoblasts Roberts (2008)
40 amino acid N-terminal region contains a relatively strong secretory signal, however all three domains of the HAD superfamily are retained in exon 3
3 - 2070 - 267 - Roberts (2008)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveboneperiosteum highly
cells
SystemCellPubmedSpeciesStageRna symbol
 chondrocyte
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a VWFC domain
  • mono polymer homomer , monomer
    HOMOLOGY
    interspecies homolog to murine Phospho1
    Homologene
    FAMILY
  • fibrillar collagen family
  • haloacid dehalogenase superfamily of Mg2+-dependent hydrolases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,cytosolic,vesicle
    text localized to sites of mineralisation in both cartilage and bone, in matrix vesicules
    basic FUNCTION
  • phosphatase capable of cleaving phosphoethanolamine (PEA) and phosphocholine to generate inorganic phosphate (Roberts 2007)
  • phosphoethanolamine/phosphocholine phosphatase that has previously been implicated in generating inorganic phosphate (P(i)) for matrix mineralization
  • implicated in the mineralization process in both osteoblasts and chondrocytes
  • exhibiting high specific activities toward phosphoethanolamine (PEA) and phosphocholine (PCho)
  • has a role in the mineralization process which is likely to be in the production of Pi for calcium phosphate precipitation
  • plays a role in the initiation of matrix mineralization (Roberts 2007)
  • prominent non-redundant roles for both PHOSPHO1 and ALPL in dentin mineralization
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    glycerophospholipid metabolism
    a component
  • homotrimers of alpha 1(II) chains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS