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FLASH GENE
Symbol PHLPP2 contributors: mct - updated : 02-09-2014
HGNC name PH domain and leucine rich repeat protein phosphatase 2
HGNC id 29149
Location 16q22.2      Physical location : 71.678.853 - 71.748.704
Synonym name
  • related to KIAA0606
  • PH domain and leucine rich repeat protein phosphatase-like
  • PHLPP-like
  • Synonym symbol(s) KIAA0931, PHLPPL
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 79.78 kb     18 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 7919 - 1323 - 2007 1738626
    18 - 8463 - 1256 - 2007 1738626
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   moderately
     neuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   predominantly
    Nervousbraindiencephalonamygdala highly
     braindiencephalonhypothalamus highly
     nervecranial nerve  highly
    Visualeyeretina  moderatelyHomo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PH domain
  • twenty one LRR (leucine-rich) repeats
  • a PP2C-like domain
  • phosphatase domain effectively dephosphorylates synthetic and peptidic substrates, its activity is modulated by metals and lipophilic compounds, and it has relatively high thermal stability
  • HOMOLOGY
    interspecies homolog to murine Phlppl (90.9 pc)
    intraspecies homolog to PHLPP
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text peripheral membrane protein
    basic FUNCTION
  • inactivating AKT1
  • inhibiting cell-cycle progression
  • promoting apoptosis
  • Ser/Thr protein phosphatase implicated in the regulation of various signaling pathways (Masubuchi 2010)
  • PHLPP1, PHLPP2 are novel player involved in regulating protein translation initiation and cell size via direct dephosphorylation of RPS6KB1
  • PHLPP1, PHLPP2 dephosphorylate AKT1 to limit its activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mn2+ (2 ions per subunit)
  • protein
  • ADCY6 was physically associated with PHLPP2, which prevents PHLPP2-mediated AKT1 dephosphorylation
  • USP12, in complex with WDR48 and WDR20, directly deubiquitinates and stabilises the AKT1 phosphatases PHLPP1 and PHLPP2 resulting in decreased levels of active AKT1
  • CNTN1 enhances AKT1 activation in part by preventing PHLPP2-mediated AKT1 dephosphrorylation
  • interacts with IKBKB, decreases its phosphorylation and the subsequent NFKB activation in cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • biomarker of cancer progression, implicating it as major negative regulator of NFKB signaling
  • Therapy target
    ANIMAL & CELL MODELS