Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PHKG2 contributors: mlc/np - updated : 17-05-2013
HGNC name phosphorylase kinase, gamma 2 (testis)
HGNC id 8931
Corresponding disease
GSD9C glycogen storage disease, type IX C
Location 16p11.2      Physical location : 30.759.619 - 30.772.495
Synonym name
  • phosphorylase kinase, gamma 2 (testis/liver)
  • phosphorylase b kinase gamma catalytic chain, testis/liver isoform
    • Synonym symbol(s) PSK-C3, PHK-gamma-T
    EC.number 2.7.11.26, 2.7.11.19
    DNA
    TYPE functioning gene
    STRUCTURE 12.88 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC387619 16 PI-3-kinase-related kinase SMG-1 LOC390689 16 similar to carbonic anhydrase VA, mitochondrial precursor; carbonic anhydrase V, mitochondrial; carbonic dehydratase CD2BP2 16p12.1 CD2 antigen (cytoplasmic tail) binding protein 2 DKFZP434P1750 16p12.1 DKFZP434P1750 protein HUMMLC2B 16p12.1 myosin light chain 2 SEPT1 16q11.1 septin 1 FLJ31751 16p12.1 hypothetical protein FLJ31751 LOC51333 16p12.1 mesenchymal stem cell protein DSC43 XTP3TPA 16p12.1 XTP3-transactivated protein A SEPHS2 16p12.1 selenophosphate synthetase 2 ITGAL 16p11.2 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) FLJ23436 16p11.2 hypothetical protein FLJ23436 MGC2474 16p11.2 hypothetical protein MGC2474 LOC388244 16 LOC388244 MGC13138 16p11.2 hypothetical protein MGC13138 LOC146542 16p11.2 similar to hypothetical protein MGC13138 FLJ32130 16p11.2 hypothetical protein FLJ32130 LOC115509 16p11.2 hypothetical protein BC014000 MGC3121 16p11.2 hypothetical protein MGC3121 FBS1 16p11.2 fibrosin 1 LOC388245 16 LOC388245 SRCAP 16p11.2 LOC388245 PHKG2 16p11.2-p12.1 phosphorylase kinase, gamma 2 (testis) LOC388246 16 LOC388246 RNF40 16p11.2-p11.1 ring finger protein 40 KIAA0326 16p11 ring finger protein 40 LOC390690 16 similar to Protein C20orf27 BCL7C 16p11 B-cell CLL/lymphoma 7C CTF1 16p11.2-p11.1 cardiotrophin 1 LOC283932 16p11.2 hypothetical protein LOC283932 MGC13024 16p11.2 hypothetical protein MGC13024 KIAA0339 16p11 hypothetical protein MGC13024 HSD3B7 16p11.2-12 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 STX1B2 16p12-p11 syntaxin 1B2 STX4A 16p13.13-p12.3 syntaxin 4A (placental) FLJ13479 16p11.2 hypothetical protein FLJ13479 KIAA0296 16p13.13-p13.2 hypothetical protein FLJ13479 IMAGE3455200
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 5503 46.4 406 - 2007 17689125
    11 - 2307 - 374 - 2007 17689125
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     liver    
    Lymphoid/Immunethymus   predominantly
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary  moderately
     male systemtestis  moderately
     male systemprostate  moderately
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , oligo
    HOMOLOGY
    interspecies ortholog to rattus Phkg2
    ortholog to murine Phkg2
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the phosphorylation of serine in certain substrates, including troponin I
  • may regulate glycogeneolysis in the testis
  • acting as a protein serine/threonine kinase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • glycogen biosynthesis
    • a component
  • polymer of 16 chains, four each of alpha, beta, gamma, and delta (alpha and beta are regulatory chains, gamma is the catalytic chain, and delta is calmodulin)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • calmodulin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD9C
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS